ArticleSouth Asian journal of cancer
Correlation of digital mammography and digital breast tomosynthesis features of self-detected breast cancers with human epidermal growth factor receptor type 2/neu status.
Article in South Asian journal of cancer. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 4 citations in OpenAlex.
- Preliminary study on DCE-MRI radiomics analysis for differentiation of HER2-low and HER2-zero breast cancer.Frontiers in oncology · 2024Article
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7 authors at 1 institution in 1 country.
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Abstract
contextBreast cancer is a heterogeneous disease with several histological subtypes. Its prognosis and management are influenced by human epidermal growth factor receptor type 2 (HER2/neu) expression. Varying grades of HER2/neu overexpression are likely to have different morphological features. Digital breast tomosynthesis (DBT) enhances lesion visibility and hence that it may reveal features closer to histomorphological findings.
aimsThe aim of this study is to correlate digital mammography (DM) and DBT findings of self-detected tumors with HER2/neu status, to determine whether differences in imaging features can help predict the degrees of HER2/neu overexpression. SETTINGS AND
designProspective study conducted in a tertiary care hospital.
methodsFor 100 consecutive patients with self-detected lumps, DM and DBT data were reviewed by two radiologists who were blinded to histopathology. Of these, 63 patients with histologically proven breast cancer were recruited and their DM and DBT findings compared and correlated with HER2neu status (scores 0-3+). STATISTICAL ANALYSIS: Pearson's Chi-squared test and Fisher's exact test were used (SPSS version 22.0, IBM).
resultsMorphology of lesions at both DM and DBT varied with HER2/neu status (
conclusionDM and DBT features vary with the intensity of HER2 immunostaining. Higher BI-RADS scores, microcalcifications, and spiculated margins are frequently associated with HER2/neu 3+ lesions.
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