Evidence map›Paper›PMID 31489279›Full record

ReviewJournal of comorbidity

Prevalence of multimorbidity in community settings: A systematic review and meta-analysis of observational studies.

Hai Nguyen, Gergana Manolova, Christina Daskalopoulou, Silia Vitoratou, Martin Prince, A Matthew Prina

3 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of comorbidity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 325 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
325citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05311410 naunknown statusnot on this map

Viral Kinetics of SARS-CoV-2 in Patients in the Intensive Care Unit Undergoing Dental Procedures

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2021 to 2025Enrolled60ConditionsSARS-CoV2 Infection, Viral Load, Oral Diseases, Dental TreatmentArmsNon-bloody dental procedures (control group), Bloody dental procedures (study group)
NCT06248190 nacompletednot on this map

Effectiveness of a Health Systems Strengthening Intervention to Improve Detection, Treatment, and Control of Multiple Long-Term Conditions in Primary Health Care Facilities in the Western Cape and KwaZulu Natal, South Africa

TypeinterventionalSponsorUniversity of KwaZuluRan2023 to 2025Enrolled1,837ConditionsHIV Infections, Hypertension, Diabetes Mellitus, AsthmaArmsENHANCE intervention (health systems)
NCT06440447 not yet recruitingnot on this map

EXploring Patterns of Use and Effects of Adult Day Programs to Improve Trajectories of Continuing CarE (EXPEDITE)

TypeobservationalSponsorYork UniversityRan2025 to 2027Enrolled500,000ConditionsAdult Day Programs, Continuing Care, Old Age, DementiaArmsAdult day program use, Other community care (non-attendees)
3 · Its place in the literature

Who cites it

325 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  12. Determinants of multimorbidity in low- and middle-income countries: A systematic review of longitudinal studies and discovery of evidence gaps.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024
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  14. Prevalence of Multimorbidity in the Middle East: A Systematic Review of Observational Studies.International journal of environmental research and public health · 2022
    Pooled it
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  19. Clinical empathy and relational continuity mitigate care fragmentation for patients with multiple long-term conditions: a qualitative study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026
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265 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hai NguyenInstitute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research Department, King's College London, London, UK.ORCID https://orcid.org/0000-0003-2171-1955
Gergana ManolovaInstitute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research Department, King's College London, London, UK.
Christina DaskalopoulouInstitute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research Department, King's College London, London, UK.
Silia VitoratouInstitute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research Department, King's College London, London, UK.
Martin PrinceInstitute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research Department, King's College London, London, UK.
A Matthew PrinaInstitute of Psychiatry, Psychology and Neuroscience, Health Service and Population Research Department, King's College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith ageing world populations, multimorbidity (presence of two or more chronic diseases in the same individual) becomes a major concern in public health. Although multimorbidity is associated with age, its prevalence varies. This systematic review aimed to summarise and meta-analyse the prevalence of multimorbidity in high, low- and middle-income countries (HICs and LMICs).

methodsStudies were identified by searching electronic databases (Medline, Embase, PsycINFO, Global Health, Web of Science and Cochrane Library). The term 'multimorbidity' and its various spellings were used, alongside 'prevalence' or 'epidemiology'. Quality assessment employed the Newcastle-Ottawa scale. Overall and stratified analyses according to multimorbidity operational definitions, HICs/LMICs status, gender and age were performed. A random-effects model for meta-analysis was used.

resultsSeventy community-based studies (conducted in 18 HICs and 31 LMICs) were included in the final sample. Sample sizes ranged from 264 to 162,464. The overall pooled prevalence of multimorbidity was 33.1% (95% confidence interval (CI): 30.0-36.3%). There was a considerable difference in the pooled estimates between HICs and LMICs, with prevalence being 37.9% (95% CI: 32.5-43.4%) and 29.7% (26.4-33.0%), respectively. Heterogeneity across studies was high for both overall and stratified analyses (

conclusionA large proportion of the global population, especially those aged 65+, is affected by multimorbidity. To allow accurate estimations of disease burden, and effective disease management and resources distribution, a standardised operationalisation of multimorbidity is needed.

Indexed as

HICsLMICsMultimorbidityprevalence

Identifiers

PMID31489279
PMCPMC6710708

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.