Evidence map›Paper›PMID 31489134›Full record

ArticleEuropean journal of psychotraumatology2019

Circulating levels of oxytocin may be elevated in complicated grief: a pilot study.

Eric Bui, Samantha N Hellberg, Susanne S Hoeppner, Peter Rosencrans, Allison Young, Rachel A Ross, Elizabeth Hoge, Naomi M Simon

Open access · goldAbstract read
In one paragraph

Article in European journal of psychotraumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Prolonged grief disorder in later life: advancing our understanding of biopsychosocial mechanisms to guide future personalized interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  4. Article
  5. A pull to be close: The differentiating effects of oxytocin and grief stimulus type on approach behavior in complicated grief.European journal of trauma & dissociation = Revue europeenne du trauma et de la dissociation · 2023
    Article
  6. Article
  7. Interactions between thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Eric BuiDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-1413-6473
Samantha N HellbergDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-0302-2382
Susanne S HoeppnerDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Peter RosencransDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Allison YoungDepartment of Psychiatry, New York University School of Medicine, New York, NY, USA.
Rachel A RossDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Elizabeth HogeDepartment of Psychiatry, Georgetown University Medical Center, Georgetown, DC, USA.
Naomi M SimonDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Harvard University · USMassachusetts General Hospital · USGeorgetown University · USNew York University · US

Funding

Fostering Research Mentorship & Training during Psychiatry Residency SupplementR25MH094612 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FAVA, MAURIZIO, GREENFIELD, SHELLY F. · 2011 to 2022
$2.3M
Dissecting a novel prefrontal cortical pathway regulating feeding behaviorK08DK118201 · NIDDK · MCLEAN HOSPITAL · PI ROSS, RACHEL A · 2019 to 2022
$963k
NIDDK NIH HHS K08 DK118201NIMH NIH HHS R25 MH094612
6 · The paper itself

Abstract

Complicated grief (CG) is a debilitating syndrome characterized by persisting and intense distress and impairment after the death of a loved one. The biological mechanisms associated with this syndrome remain unclear but may involve neurobiological pathways implicated in the stress response and attachment systems. The neuropeptide oxytocin has been implicated in attachment and social behaviour, and loss of social bonds has been associated with disruptions in oxytocin signalling. Furthermore, prior research has reported associations between circulating oxytocin and other mental illnesses, including depression. The present pilot study aimed to examine plasma levels of oxytocin in bereaved adults with primary CG (

Indexed as

Bereavementbiomarkerscomplicated griefdepressionoxytocinprolonged grief

Identifiers

PMID31489134
PMCPMC6713138
OpenAlexW2966321157

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.