ArticlePakistan journal of medical sciences
A novel comparison of Epstein-Barr virus with broad histological spectrum of oral squamous cell carcinoma.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Oncogenic viruses and their role in oral cavity and oropharyngeal squamous cell carcinoma: a systematic review.Frontiers in oncology · 2026Review
- Epstein-Barr Virus miRNAs in Multiple Sclerosis: Unveiling their role in Immune Regulation and Potential for Diagnostic and Therapeutic Innovation.Pakistan journal of medical sciences · 2025Article
- TrkA Expression as a Novel Prognostic Biomarker in Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2025Article
- Efficacy of total laparoscopic hysterectomy without uterine manipulators in patient with early-stage cervical cancer.Pakistan journal of medical sciences · 2024Article
- Evaluation of Epstein-Barr virus expression in oral squamous cell carcinomas.Dental research journal · 2022Article
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3 authors.
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Abstract
objectivesTo evaluate the immunohistochemical expression of Epstein-Barr virus (EBV) in broad spectrum histological subtypes of oral squamous cell carcinoma (OSCC) and to determine the relationship of EBV with clinicopathological parameters of OSCC.
methodsThis cross-sectional study included 150 clinically diagnosed OSCC cases from the outpatient of Ziauddin University Hospital from March, 2017 to October, 2018. These were confirmed on histological examination and categorized into conventional squamous cell carcinoma (SCC) and rare variants. Conventional SCC was subcategorized into keratinizing (KSCC), non-keratinizing (NKSCC), and hybrid SCC (HSCC). EBV status was compared among various histological tumor entities and clinicopathological characteristics of OSCC using immunohistochemistry. Chi-square test was used to determine the association of each histological subtype with EBV status with P-value <0.05 considered as statistically significant.
resultsConventional tumor was the most frequent squamous cell carcinoma (n=126; 84%). A significant statistical link of EBV infection was observed with rare histological tumors exhibiting acantholysis (P=0.01), as well as tumors involving buccal mucosa (P=0.03), and habitual smokers (P=0.001).
conclusionsIn this study, acantholytic tumor, a rare histological subtype of OSCC, tended to be EBV related. Moreover, OSCC cases bearing EBV infection were more likely smokers favoring buccal mucosa as primary anatomical site for oral cancer.
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