Evidence map›Paper›PMID 31488946›Full record

ArticleCancer informatics2019

Multiple Omics Data Integration to Identify Long Noncoding RNA Responsible for Breast Cancer-Related Mortality.

Tapasree Roy Sarkar, Arnab Kumar Maity, Yabo Niu, Bani K Mallick

Open access · goldAbstract read
In one paragraph

Article in Cancer informatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tapasree Roy SarkarDepartment of Biology, Texas A&M University, College Station, TX, USA.ORCID https://orcid.org/0000-0001-8022-6760
Arnab Kumar MaityEarly Clinical Development Oncology Statistics, Pfizer Inc, San Diego, CA, USA.
Yabo NiuDepartment of Statistics, Texas A&M University, College Station, TX, USA.
Bani K MallickDepartment of Statistics, Texas A&M University, College Station, TX, USA.
Texas A&M University · USPfizer (United States) · US

Funding

Graph-based Bayesian analysis of Genomics and Proteomics DataR01CA194391 · NCI · TEXAS A&M UNIVERSITY · PI BALADANDAYUTHAPANI, VEERABHADRAN, MALLICK, BANI K · 2016 to 2020
$2.0M
NCI NIH HHS R01 CA194391
6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are a large and diverse class of transcribed RNAs, which have been shown to play a significant role in developing cancer. In this study, we apply integrative modeling framework to integrate the DNA copy number variation (CNV), lncRNA expression, and downstream target protein expression to predict patient survival in breast cancer. We develop a 3-stage model combining a mechanical model (lncRNA regressed on CNV and target proteins regressed on lncRNA) and a clinical model (survival regressed on estimated effects from the mechanical models). Using lncRNAs (such as

Indexed as

breast cancerintegrative modelingLong noncoding RNAsurvival modelTCGA

Identifiers

PMID31488946
PMCPMC6710679
OpenAlexW2969772572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.