Evidence map›Paper›PMID 31488888›Full record

ReviewNature reviews. Endocrinology2019

Rethinking mechanisms, diagnosis and management of endometriosis.

Charles Chapron, Louis Marcellin, Bruno Borghese, Pietro Santulli

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 488 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
488citing papers in PubMed, 9 pooled it
77.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06211569 recruitingnot on this mapstarted 2024, after this paper: background citation

Study of the Prevalence of Endometriosis and Adenomyosis in Women of Childbearing Age Consulting for Non-medical Oocyte Self-preservation

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2024 to 2028Enrolled400ConditionsElective Fertility PreservationArmsUsual follow-up
NCT06495151 completednot on this mapstarted 2022, after this paper: background citation

Evaluation of Serum and Peritoneal Fluid Mannose-binding Lectin Associated Serine Protease-3, Adipsin, Properdin, and Complement Factor H Levels in Endometriosis Patients

TypeobservationalSponsorAnkara City Hospital BilkentRan2022 to 2022Enrolled58ConditionsEndometriosis, Complement System, Alternative Complement PathwayArmsMannose-binding lectin-associated serine protease-3 (MASP-3) Level, Adipsin Level, Properdin Level, Complement Factor H (CFH) Level, Cancer Antigen 125 (CA-125) Level
NCT07282990 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evolution of Endometriosis Lesions and Quality of Life of Patients

Typeobservational_patient_registrySponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2025 to 2028Enrolled100ConditionsEndometriosis
3 · Its place in the literature

Who cites it

488 citing papers in PubMed, 9 syntheses or guidelines pooled it, 1,015 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. L-ICON3 Suppresses Endometriosis in a Murine Model.Journal of molecular medicine (Berlin, Germany) · 2026
    Article
  19. Article
  20. Review

428 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Charles ChapronUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. charles.chapron@aphp.fr.
Louis MarcellinUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
Bruno BorgheseUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
Pietro SantulliUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
Sorbonne Paris Cité · FRDélégation Paris 5 · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis is a chronic inflammatory disease defined as the presence of endometrial tissue outside the uterus, which causes pelvic pain and infertility. This disease should be viewed as a public health problem with a major effect on the quality of life of women as well as being a substantial economic burden. In light of the considerable progress with diagnostic imaging (for example, transvaginal ultrasound and MRI), exploratory laparoscopy should no longer be used to diagnose endometriotic lesions. Instead, diagnosis of endometriosis should be based on a structured process involving the combination of patient interviews, clinical examination and imaging. Notably, a diagnosis of endometriosis often leads to immediate surgery. Therefore, rethinking the diagnosis and management of endometriosis is warranted. Instead of assessing endometriosis on the day of the diagnosis, gynaecologists should consider the patient's 'endometriosis life'. Medical treatment is the first-line therapeutic option for patients with pelvic pain and no desire for immediate pregnancy. In women with infertility, careful consideration should be made regarding whether to provide assisted reproductive technologies prior to performing endometriosis surgery. Modern endometriosis management should be individualized with a patient-centred, multi-modal and interdisciplinary integrated approach.

Indexed as

Disease ManagementEndometriosisFemaleHealth PersonnelHumansPatient-Centered Care

Identifiers

PMID31488888
OpenAlexW2971722175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.