ArticleScientific reports2019
Active behaviour during early development shapes glucocorticoid reactivity.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physiology can predict animal activity, exploration, and dispersal.Communications biology · 2022Pooled it
- Early life chronic stress-disrupted activity of the dorsal raphe nucleus selectively drives behavioral impairments.Communications biology · 2026Article
- Extracellular matrix proteolysis maintains synapse plasticity during brain development.Nature neuroscience · 2026Article
- Thymol and menthol as anaesthetics for short transportation of zebrafish larva.Fish physiology and biochemistry · 2025Article
- Behavioral, metabolic, and biochemical alterations caused by an acute stress event in a zebrafish larvae model.Fish physiology and biochemistry · 2025Article
- Early-life challenge enhances cortisol regulation in zebrafish larvae.Biology open · 2024Article
- Cortisol dynamics and GR-dependent feedback regulation in zebrafish larvae exposed to repeated stress.Biology open · 2024Article
- Altered glucocorticoid reactivity and behavioral phenotype in rx3-/- larval zebrafish.Frontiers in endocrinology · 2023Article
- Deficiency in the cell-adhesion moleculeFrontiers in cell and developmental biology · 2023Article
- Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish.Scientific reports · 2022Article
- Environmental and Molecular Modulation of Motor Individuality in Larval Zebrafish.Frontiers in behavioral neuroscience · 2021Article
- Early-life stress influences ion balance in developing zebrafish (Danio rerio).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- The Effects of Early Life Stress on the Brain and Behaviour: Insights From Zebrafish Models.Frontiers in cell and developmental biology · 2021Review
- Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood.BMC research notes · 2020Article
- Chronic unpredictable stress induces anxiety-like behaviors in young zebrafish.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoids are the final effectors of the stress axis, with numerous targets in the central nervous system and the periphery. They are essential for adaptation, yet currently it is unclear how early life events program the glucocorticoid response to stress. Here we provide evidence that involuntary swimming at early developmental stages can reconfigure the cortisol response to homotypic and heterotypic stress in larval zebrafish (Danio rerio), also reducing startle reactivity and increasing spontaneous activity as well as energy efficiency during active behaviour. Collectively, these data identify a role of the genetically malleable zebrafish for linking early life stress with glucocorticoid function in later life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.