ArticleNature communications2019
Neural sensitization improves encoding fidelity in the primate retina.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates.Vision research · 2026Review
- Surround motion modulates the encoding properties of primate retinal ganglion cells.Cell reports · 2026Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- Response Plasticity ofInternational journal of molecular sciences · 2024Article
- GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells.Cognitive neurodynamics · 2024Article
- An artificial visual neuron with multiplexed rate and time-to-first-spike coding.Nature communications · 2024Article
- Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Suppression without inhibition: how retinal computation contributes to saccadic suppression.Communications biology · 2022Article
- Inhibition, but not excitation, recovers from partial cone loss with greater spatiotemporal integration, synapse density, and frequency.Cell reports · 2022Article
- Predictive encoding of motion begins in the primate retina.Nature neuroscience · 2021Article
- Synaptic inputs to broad thorny ganglion cells in macaque retina.The Journal of comparative neurology · 2021Article
- Efficient and adaptive sensory codes.Nature neuroscience · 2021Article
- Functional-pathway-dominant contrast adaptation and sensitization in mouse retinal ganglion cells.Cognitive neurodynamics · 2020Article
- Article
- High Contrast Allows the Retina to Compute More Than Just Contrast.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
An animal's motion through the environment can induce large and frequent fluctuations in light intensity on the retina. These fluctuations pose a major challenge to neural circuits tasked with encoding visual information, as they can cause cells to adapt and lose sensitivity. Here, we report that sensitization, a short-term plasticity mechanism, solves this difficult computational problem by maintaining neuronal sensitivity in the face of these fluctuations. The numerically dominant output pathway in the macaque monkey retina, the midget (parvocellular-projecting) pathway, undergoes sensitization under specific conditions, including simulated eye movements. Sensitization is present in the excitatory synaptic inputs from midget bipolar cells and is mediated by presynaptic disinhibition from a wide-field mechanism extending >0.5 mm along the retinal surface. Direct physiological recordings and a computational model indicate that sensitization in the midget pathway supports accurate sensory encoding and prevents a loss of responsiveness during dynamic visual processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.