ArticleNature communications2019
Space Station conditions are selective but do not alter microbial characteristics relevant to human health.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Longitudinal analysis of stowaway microorganisms aboard modules and cargo spacecraft of the Chinese Space Station.Microbiome · 2026Article
- Bacterial resistance across habitats: from German schools to the International Space Station.Frontiers in microbiology · 2026Article
- Community matters: stress tolerance and survival ofFrontiers in microbiology · 2026Article
- Microbial fuel cell centric nutrient rebalancing and recycling from human waste in space missions.Emerging topics in life sciences · 2025Review
- Touching Surfaces - Presence of microorganisms on antimicrobial metal surfaces on the International Space Station and in German schools.BMC microbiology · 2025Article
- Article
- An early microbial landscape: inspiring endeavor from the China Space Station Habitation Area Microbiome Program (CHAMP).Science China. Life sciences · 2025Article
- Article
- The Metabolic and Physiological Responses to Spaceflight of a Lipopeptide-Producing Bacillus subtilis.Microbial biotechnology · 2025Article
- On-orbit microbial succession patterns of the China Space Station during the construction period.Microbiome · 2025Article
- Challenges for the human immune system after leaving Earth.NPJ microgravity · 2024Review
- Article
- Microbiology of human spaceflight: microbial responses to mechanical forces that impact health and habitat sustainability.Microbiology and molecular biology reviews : MMBR · 2024Review
- Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).Nature communications · 2024Article
- Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions.Nature communications · 2024Article
- Microbiome in a ground-based analog cabin of China Space Station during a 50-day human occupation.ISME communications · 2024Article
- Whole genome-scale assessment of gene fitness of Novosphingobium aromaticavorans during spaceflight.BMC genomics · 2023Article
- Article
- Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes.Scientific reports · 2023Article
- Astrovirology: how viruses enhance our understanding of life in the Universe.International journal of astrobiology · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The International Space Station (ISS) is a unique habitat for humans and microorganisms. Here, we report the results of the ISS experiment EXTREMOPHILES, including the analysis of microbial communities from several areas aboard at three time points. We assess microbial diversity, distribution, functional capacity and resistance profile using a combination of cultivation-independent analyses (amplicon and shot-gun sequencing) and cultivation-dependent analyses (physiological and genetic characterization of microbial isolates, antibiotic resistance tests, co-incubation experiments). We show that the ISS microbial communities are highly similar to those present in ground-based confined indoor environments and are subject to fluctuations, although a core microbiome persists over time and locations. The genomic and physiological features selected by ISS conditions do not appear to be directly relevant to human health, although adaptations towards biofilm formation and surface interactions were observed. Our results do not raise direct reason for concern with respect to crew health, but indicate a potential threat towards material integrity in moist areas.
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