Evidence map›Paper›PMID 31488811›Full record

ArticleTranslational psychiatry2019

Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA

A Limon, E Delbruck, A Yassine, D Pandya, R M Myers, J D Barchas, F Lee, Schatzberg, S J Watson, H Akil and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Massive Activation of GABABiomolecules · 2025
    Review
  4. Article
  5. Electrophysiology of ionotropic GABA receptors.Cellular and molecular life sciences : CMLS · 2021
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

A LimonDepartment of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA. agenor.limon@utmb.edu.ORCID http://orcid.org/0000-0002-6613-770X
E DelbruckDepartment of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA.
A YassineDepartment of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA.
D PandyaDepartment of Neurology, Mitchel Center for Neurodegenerative Diseases, School of Medicine, University of Texas Medical Branch at Galveston, Galveston, USA.
R M MyersHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
J D BarchasDepartment of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
F LeeDepartment of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
SchatzbergDepartment of Psychiatry & Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
S J WatsonMolecular and Behavioral Neurosciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-4980-5523
H AkilMolecular and Behavioral Neurosciences Institute, University of Michigan, Ann Arbor, MI, USA.
W E BunneyDepartment of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA.
M P VawterDepartment of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA.
A SequeiraDepartment of Psychiatry and Human Behavior. School of Medicine, University of California Irvine, Irvine, USA. psequeir@uci.edu.
University of California, Irvine · USCornell University · USNeurosciences Institute · USHudsonAlpha Institute for Biotechnology · USStanford University · USThe University of Texas Medical Branch at Galveston · US

Funding

Mitochondrial Dysfunction In SchizophreniaR01MH085801 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAWTER, MARQUIS PHILIP · 2009 to 2020
$5.0M
Synaptic Imbalance in Mild Cognitive Impairment and Alzheimer's DiseaseR21AG053740 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAUTERBORN, JULIE C, LIMON, AGENOR · 2016 to 2017
$425k
Multidimensional Analysis of Synaptic Dysfunction in SchizophreniaR21MH113177 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMON, AGENOR, VAWTER, MARQUIS PHILIP · 2017 to 2018
$425k
NIA NIH HHS R21 AG053740NIMH NIH HHS R01 MH085801NIMH NIH HHS R21 MH113177
6 · The paper itself

Abstract

Polyamines have fundamental roles in brain homeostasis as key modulators of cellular excitability. Several studies have suggested alterations in polyamine metabolism in stress related disorders, suicide, depression, and neurodegeneration, making the pharmacological modulation of polyamines a highly appealing therapeutic strategy. Polyamines are small aliphatic molecules that can modulate cationic channels involved in neuronal excitability. Previous indirect evidence has suggested that polyamines can modulate anionic GABA

Indexed as

HumansHydrogen-Ion ConcentrationNeuronsOocytesPrefrontal CortexReceptors, GABA-ASpermineSynapsesSynaptic MembranesReceptors, GABA-ASpermine

Identifiers

PMID31488811
PMCPMC6728327
OpenAlexW2971681635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.