Evidence map›Paper›PMID 31488708›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Oxidative stress drives the selection of quorum sensing mutants in the

Shilpa Elizabeth George, Jennifer Hrubesch, Inga Breuing, Naisa Vetter, Natalya Korn, Katja Hennemann, Lisa Bleul, Matthias Willmann, Patrick Ebner, Friedrich Götz and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 42 citations in OpenAlex.

  1. SkinApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Linking Virulence and Iron Limitation Response inJournal of proteome research · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Quorum-sensingeLife · 2024
    Article
  9. Quorum-sensingbioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Identification ofVirulence · 2023
    Article
  13. Review
  14. Putrescine Detected in Strains ofPathogens (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Article
  17. Applied and environmental microbiology · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Shilpa Elizabeth GeorgeInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Jennifer HrubeschInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Inga BreuingInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Naisa VetterInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Natalya KornInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Katja HennemannInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Lisa BleulInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Matthias WillmannInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.ORCID 0000-0003-0095-4640
Patrick EbnerInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Friedrich GötzInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany.
Christiane WolzInterfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen 72076, Germany christiane.wolz@med.uni-tuebingen.de.ORCID 0000-0003-3909-5281
University of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quorum sensing (QS) is the central mechanism by which social interactions within the bacterial community control bacterial behavior. QS-negative cells benefit by exploiting public goods produced by the QS-proficient population. Mechanisms to keep the balance between producers and nonproducers within the population are expected but have not been elucidated for peptide-based QS systems in gram-positive pathogens. The Agr system of

Indexed as

MutationOxidative StressQuorum SensingBacterial ProteinsBacterial ToxinsEvolution, MolecularGene Expression Regulation, BacterialStaphylococcal InfectionsStaphylococcus aureusTrans-ActivatorsVirulenceAgr protein, Staphylococcus aureusBacterial ProteinsBacterial Toxinsstaphylococcal delta toxinTrans-ActivatorsAgroxidative stressPSMsquorum sensingStaphylococcus aureus

Identifiers

PMID31488708
PMCPMC6754547
OpenAlexW2972119014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.