Evidence map›Paper›PMID 31488707›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Phase variation in

Hassan Safi, Pooja Gopal, Subramanya Lingaraju, Shuyi Ma, Carly Levine, Veronique Dartois, Michelle Yee, Liping Li, Landry Blanc, Hsin-Pin Ho Liang and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

  1. Pooled it
  2. MakingCell insight · 2026
    Review
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  4. Article
  5. Review
  6. Article
  7. A new Persister Enrichment Model inbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Hassan SafiCenter for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ 07103; safiha@njms.rutgers.edu david.alland@rutgers.edu.
Pooja GopalDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Republic of Singapore.
Subramanya LingarajuCenter for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Shuyi MaCenter for Infectious Disease, Seattle Children's Hospital, Seattle, WA 98105.
Carly LevineCenter for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Veronique DartoisThe Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Michelle YeeDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Republic of Singapore.
Liping LiThe Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Landry BlancThe Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ 07103.ORCID 0000-0001-5622-356X
Hsin-Pin Ho LiangThe Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Seema HusainGenomics Center, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Mainul HoqueGenomics Center, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Patricia SoteropoulosGenomics Center, New Jersey Medical School, Rutgers University, Newark, NJ 07103.
Tige RustadCenter for Infectious Disease, Seattle Children's Hospital, Seattle, WA 98105.
David R ShermanCenter for Infectious Disease, Seattle Children's Hospital, Seattle, WA 98105.
Thomas DickCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
David AllandCenter for Emerging Pathogens, New Jersey Medical School, Rutgers University, Newark, NJ 07103; safiha@njms.rutgers.edu david.alland@rutgers.edu.
Rutgers, The State University of New Jersey · USSeattle Children's Hospital · USNational University of Singapore · SGHackensack Meridian Health · US

Funding

Validation and Application of a Model for Human-like TB Latency in RabbitsU19AI111276 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ALLAND, DAVID, ELLNER, JERROLD J. · 2014 to 2020
$23.3M
Target based discovery of next generation pyrazinamideR01AI106398 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DICK, THOMAS · 2013 to 2022
$7.1M
Diseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3M
De facto monotherapy during multidrug TB treatment and emergence of resistanceR01AI111967 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ALLAND, DAVID, DARTOIS, VERONIQUE · 2014 to 2018
$4.2M
Program in Infection, Immunity and InflammationT32AI125185 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI SALGAME, PADMINI · 2016 to 2020
$747k
NIAID NIH HHS R01 AI106398NIAID NIH HHS R01 AI111967NIAID NIH HHS T32 AI007509NIAID NIH HHS T32 AI125185NIAID NIH HHS U19 AI111276
6 · The paper itself

Abstract

The length and complexity of tuberculosis (TB) therapy, as well as the propensity of

Indexed as

AnimalsAntitubercular AgentsBacterial ProteinsDrug Resistance, Multiple, BacterialDrug ToleranceFemaleGlycerol KinaseMiceMice, Inbred BALB CMicrobial Sensitivity TestsMycobacterium tuberculosisPromoter Regions, GeneticTuberculosisAntitubercular AgentsBacterial ProteinsGlycerol KinaseglpKMycobacterium tuberculosisphase variationreversible drug tolerancesmall colony variant

Identifiers

PMID31488707
PMCPMC6765255
OpenAlexW2971364670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.