Evidence map›Paper›PMID 31488706›Full record

ArticleScience (New York, N.Y.)2019

A lineage-resolved molecular atlas of

Jonathan S Packer, Qin Zhu, Chau Huynh, Priya Sivaramakrishnan, Elicia Preston, Hannah Dueck, Derek Stefanik, Kai Tan, Cole Trapnell, Junhyong Kim and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 331 papers.

0numbers the graph read from it
0cells of the map it votes in
331citing papers in PubMed
25.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

331 citing papers in PubMed, 603 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. An atlas of thebioRxiv : the preprint server for biology · 2026
    Article
  6. Article
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  18. Article
  19. Transcriptomic profiling of the embryonicbioRxiv : the preprint server for biology · 2026
    Article
  20. A pilot study for whole proteome tagging inbioRxiv : the preprint server for biology · 2026
    Article

271 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jonathan S PackerDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4025-0007
Qin ZhuGenomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5539-6071
Chau HuynhDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Priya SivaramakrishnanDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8717-8287
Elicia PrestonDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9209-5956
Hannah DueckDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3324-4357
Derek StefanikDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9351-6804
Kai TanDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-9104-5567
Cole TrapnellDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8105-4347
Junhyong KimDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA. junhyong@sas.upenn.edu watersto@uw.edu jmurr@pennmedicine.upenn.edu.ORCID 0000-0002-7726-8246
Robert H WaterstonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA. junhyong@sas.upenn.edu watersto@uw.edu jmurr@pennmedicine.upenn.edu.ORCID 0000-0001-5956-5215
John I MurrayDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. junhyong@sas.upenn.edu watersto@uw.edu jmurr@pennmedicine.upenn.edu.ORCID 0000-0003-4026-584X
University of Pennsylvania · USUniversity of Washington · USChildren's Hospital of Philadelphia · US

Funding

Resource ProjectU41HG007355 · NHGRI · UNIVERSITY OF WASHINGTON · PI WATERSTON, ROBERT H · 2013 to 2021
$20.8M
Data Analysis UnitU2CCA233285 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI HUNGER, STEPHEN PATRICK, TAN, KAI · 2018 to 2023
$13.2M
Center for Sub-Cellular GenomicsRM1HG010023 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI EBERWINE, JAMES H, KIM, JUNHYONG · 2018 to 2022
$11.0M
Automated single-cell expression analysis in C. elegansR01GM072675 · NIGMS · UNIVERSITY OF WASHINGTON · PI WATERSTON, ROBERT H · 2005 to 2017
$7.1M
Pulmonary Macrophage Transplantation for Pulmonary Alveolar ProteinosisR01HL118342 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TRAPNELL, BRUCE C, TRAPNELL, BRUCE COLSTON · 2014 to 2021
$4.5M
Charting the regulatory topography of the cell differentiation landscape with single-cell RNA-Seq.DP2HD088158 · NICHD · UNIVERSITY OF WASHINGTON · PI TRAPNELL, BRUCE COLSTON · 2015 to 2015
$2.3M
Decoding lineage and fate specification in the C. elegans embryoR35GM127093 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MURRAY, JOHN ISAAC · 2018 to 2022
$2.0M
Single cell reconstruction of lineages and variability in C. elegans embryosR21HD085201 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI MURRAY, JOHN ISAAC · 2015 to 2016
$438k
NCI NIH HHS U2C CA233285NHGRI NIH HHS RM1 HG010023NHGRI NIH HHS U41 HG007355NHLBI NIH HHS R01 HL118342NICHD NIH HHS DP2 HD088158NICHD NIH HHS R21 HD085201NIGMS NIH HHS R01 GM072675NIGMS NIH HHS R35 GM127093
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell LineageEmbryonic DevelopmentAnimalsCaenorhabditis elegansCell DifferentiationGene Expression Regulation, DevelopmentalRNA-SeqSingle-Cell AnalysisTranscriptome

Identifiers

PMID31488706
PMCPMC7428862
OpenAlexW2972184354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.