Evidence map›Paper›PMID 31488688›Full record

ArticleScience (New York, N.Y.)2019

Evaluation of an antibody to α

M Di Mascio, J D Lifson, S Srinivasula, I Kim, P DeGrange, B F Keele, A J Belli, K A Reimann, Y Wang, M Proschan and 2 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Quantitative PET imaging of the CD4 pool in nonhuman primates.European journal of nuclear medicine and molecular imaging · 2022
    Article
  8. Review
  9. Endothelial Cells Promote Productive HIV Infection of Resting CD4AIDS research and human retroviruses · 2022
    Article
  10. Early treatment with anti-αFrontiers in immunology · 2022
    Article
  11. Blocking αScience translational medicine · 2021
    Article
  12. Article
  13. Article
  14. Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV-infected rhesus macaques.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  15. Preferential Infection of α4β7+ Memory CD4+ T Cells During Early Acute Human Immunodeficiency Virus Type 1 Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

M Di MascioAIDS Imaging Research Section, Division of Clinical Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892, USA. mdimascio@niaid.nih.gov.ORCID 0000-0001-6609-9689
J D LifsonAIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA.ORCID 0000-0002-9494-0268
S SrinivasulaClinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0003-1867-5762
I KimApplied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0001-5998-0953
P DeGrangeBattelle/Charles River-Integrated Research Facility, NIAID Frederick, Frederick, MD 21702, USA.ORCID 0000-0002-7705-9831
B F KeeleAIDS and Cancer Virus Program, Frederick National Laboratory, Frederick, MD 21702, USA.ORCID 0000-0002-2381-1151
A J BelliMassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.ORCID 0000-0002-9598-115X
K A ReimannMassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.ORCID 0000-0003-3074-6500
Y WangLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20892, USA.
M ProschanBiostatistics Research Branch, Division of Clinical Research, NIAID, NIH, Bethesda, MD 20852, USA.ORCID 0000-0002-9161-3739
H C LaneLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-9509-1045
A S FauciLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-7865-7235
Frederick National Laboratory for Cancer Research · USOffice of Extramural Research · USUniversity of Massachusetts Chan Medical School · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Resource for Nonhuman Primate Cell Depleting AntibodiesR24OD010976 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ENGELMAN, KATHLEEN, MAGNANI, DIOGO · 2012 to 2019
$4.7M
NIAID NIH HHS U24 AI126683NIH HHS P51 OD011106NIH HHS R24 OD010976
6 · The paper itself

Abstract

Treatment of SIV-infected rhesus macaques with short-term antiretroviral therapy (ART) and partially overlapping infusions of antibody to integrin α

Indexed as

AnimalsAntibodies, MonoclonalAnti-Retroviral AgentsCD4 Lymphocyte CountCD4-Positive T-LymphocytesCodon, TerminatorHIV InfectionsIntegrin alpha4Integrin beta ChainsLymph NodesMacaca mulattaRectumRNA, ViralSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusViral LoadAntibodies, MonoclonalAnti-Retroviral AgentsCodon, TerminatorIntegrin alpha4integrin beta7Integrin beta ChainsNEF protein, SIVRNA, ViralViral Regulatory and Accessory Proteins

Identifiers

PMID31488688
PMCPMC11931412
OpenAlexW2972265293

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.