Evidence map›Paper›PMID 31488618›Full record

Trial reportThe oncologist2019

Pediatric NUT Carcinoma Is a Rare and Challenging Tumor: Single Center Experience of Five Children.

Maya Prasad, Akshay Baheti, Mukta Ramadwar, Girish Chinnaswamy, Tushar Vora, Sajid Qureshi

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in The oncologist, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Metastatic NUT Carcinoma in a Child.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  4. The expanding universe of NUTM1 fusions in pediatric cancer.Clinical and translational science · 2023
    Review
  5. Article
  6. Article
  7. NUT Carcinoma-An Underdiagnosed Malignancy.Frontiers in oncology · 2022
    Review
  8. Skin adnexal carcinoma with BRD3-NUTM2B fusion.Journal of cutaneous pathology · 2021
    Article
  9. Nuclear protein in testis midline carcinoma in a Turkish boy: a case report.Asian biomedicine : research, reviews and news · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maya PrasadDepartment of Pediatric Oncology, Tata Memorial Hospital, Mumbai, India Maya.prasad@gmail.com.ORCID 0000-0003-0127-7987
Akshay BahetiDepartment of Radiodiagnosis, Tata Memorial Hospital, Mumbai, India.
Mukta RamadwarDepartment of Pathology, Tata Memorial Hospital, Mumbai, India.
Girish ChinnaswamyDepartment of Pediatric Oncology, Tata Memorial Hospital, Mumbai, India.
Tushar VoraDepartment of Pediatric Oncology, Tata Memorial Hospital, Mumbai, India.
Sajid QureshiPediatric Surgery, Tata Memorial Hospital, Mumbai, India.
Homi Bhabha National Institute · INTata Memorial Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNuclear protein of the testis (NUT) carcinoma is a rare and aggressive malignancy associated with rearrangements of the nuclear protein of the testis (NUT) gene on chromosome 15q14. Because of its rarity, this tumor is often underdiagnosed and underreported, and there is limited literature regarding its biology and optimal management. METHODS AND

resultsWe report our experience of five patients with pediatric NUT carcinoma, all of whom presented with midline head and neck mass. In spite of aggressive multimodality treatment, only one patient survives.

conclusionNUT carcinoma has a dismal prognosis in spite of aggressive multimodality management (surgery and adjuvant chemotherapy and/or radiation). Novel strategies are required to improve outcomes of patients with this tumor.

Indexed as

AdolescentAdultCarcinoma, Squamous CellChildCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm ProteinsNuclear ProteinsOncogene ProteinsPrognosisRetrospective StudiesYoung AdultNeoplasm ProteinsNuclear ProteinsNUTM1 protein, humanOncogene Proteins

Identifiers

PMID31488618
PMCPMC6853094
OpenAlexW2971974895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.