ArticleThe Journal of cell biology2019
Hair follicle regeneration suppresses Ras-driven oncogenic growth.
Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle.Science (New York, N.Y.) · 2026Article
- Long-Term Latency of Highly Mutated Cells in Normal Mouse Skin Is Reversed by Exposure to Tumor Promoters and Chronic Tissue Damage.Cancer discovery · 2025Article
- Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression.Cancer discovery · 2025Article
- Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations.Nature cell biology · 2025Article
- Stromal KITL/SCF promotes pancreas tissue homeostasis and restrains tumor progression.bioRxiv : the preprint server for biology · 2024Article
- Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.Nature cell biology · 2024Article
- Article
- Volume imaging to interrogate cancer cell-tumor microenvironment interactions in space and time.Frontiers in immunology · 2023Review
- A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing.Nature communications · 2022Article
- Basal cell carcinomas acquire secondary mutations to overcome dormancy and progress from microscopic to macroscopic disease.Cell reports · 2022Article
- Loss of 'Epidermal Melanin Unit' Integrity in Human Skin During Melanoma-Genesis.Frontiers in oncology · 2022Review
- EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas.Current biology : CB · 2021Article
- Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis.Nature cell biology · 2021Article
- Diverse cellular players orchestrate regeneration after wounding.Experimental dermatology · 2021Article
- Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis.Life science alliance · 2020Article
- The duality of human oncoproteins: drivers of cancer and congenital disorders.Nature reviews. Cancer · 2020Review
- Tools and Concepts for Interrogating and Defining Cellular Identity.Cell stem cell · 2020Review
- New insights into the functions of Cox-2 in skin and esophageal malignancies.Experimental & molecular medicine · 2020Review
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14 authors.
Funding
Abstract
Mutations associated with tumor development in certain tissues can be nontumorigenic in others, yet the mechanisms underlying these different outcomes remains poorly understood. To address this, we targeted an activating Hras mutation to hair follicle stem cells and discovered that Hras mutant cells outcompete wild-type neighbors yet are integrated into clinically normal skin hair follicles. In contrast, targeting the Hras mutation to the upper noncycling region of the skin epithelium leads to benign outgrowths. Follicular Hras mutant cells autonomously and nonautonomously enhance regeneration, which directs mutant cells into continuous tissue cycling to promote integration rather than aberrancy. This follicular tolerance is maintained under additional challenges that promote tumorigenesis in the epidermis, including aging, injury, and a secondary mutation. Thus, the hair follicle possesses a unique, enhanced capacity to integrate and contain Hras mutant cells within both homeostatic and perturbed tissue, demonstrating that in the skin, multiple, distinct mechanisms exist to suppress oncogenic growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.