ArticleGenes & development2019
USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.
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Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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60citing papers in PubMed
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Who cites it
60 citing papers in PubMed, 95 citations in OpenAlex.
- Post-Translational Modifications in Pancreatic Cancer: Mechanisms to Clinical Applications.Journal of gastroenterology and hepatology · 2026Review
- USP21 drives immune evasion in colorectal cancer via deubiquitination and stabilization of β-catenin.Cellular & molecular immunology · 2026Article
- USP21 functions as an oncogenic regulator of the Mdm2-p53 axis in colorectal cancer.Cell death discovery · 2026Article
- METTL3-Mediated m6A Methylation of USP21 Contributes to Hepatocellular Carcinoma Progression by Stabilizing H2BFS Through Deubiquitination.Biochemical genetics · 2025Article
- USP21/YBX1/HIF1-α promotes the progression of prostate cancer.Journal of translational medicine · 2025Article
- The multifaceted roles of deubiquitinating enzymes (DUBs) in pancreatic ductal adenocarcinoma.Cell death & disease · 2025Review
- Article
- Role of antidiarrheal agents nifuroxazide in antitumor multi‑target anticancer, multi‑mechanism anticancer drug (Review).Oncology letters · 2025Review
- USP1 inhibits influenza A and B virus replication in MDCK cells by mediating RIG-I deubiquitination.Cellular and molecular life sciences : CMLS · 2025Article
- USP39 promote post-translational modifiers to stimulate the progress of cancer.Discover oncology · 2025Review
- USP21 is involved in the development of chronic hepatitis B by modulating the immune microenvironment.European journal of medical research · 2025Article
- Regulation of ubiquitin-proteasome system and its relative pathways in pancreatic adenocarcinoma.BioImpacts : BI · 2025Review
- The ubiquitin-specific protease 21 is critical for cancer cell mitochondrial function and regulates proliferation and migration.The Journal of biological chemistry · 2024Article
- USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling.Oncogenesis · 2024Article
- Comprehensive analysis of the relationship between ubiquitin-specific protease 21 (USP21) and prognosis, tumor microenvironment infiltration, and therapy response in colorectal cancer.Cancer immunology, immunotherapy : CII · 2024Article
- Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1.World journal of gastrointestinal oncology · 2024Article
- circCD2AP promotes epithelial mesenchymal transition and stemness in bladder cancer by regulating FOXQ1/USP21 axis.iScience · 2024Article
- Article
- USP10 promotes pancreatic ductal adenocarcinoma progression by attenuating FOXC1 protein degradation to activate the WNT signaling pathway.International journal of biological sciences · 2024Article
- USP21 deubiquitinates and stabilizes HSP90 and ENO1 to promote aerobic glycolysis and proliferation in cholangiocarcinoma.International journal of biological sciences · 2024Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Pingping HouDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Xingdi MaDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Qiang ZhangDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Chang-Jiun WuDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Wenting LiaoDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Jun LiDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Huamin WangDepartment of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Jun ZhaoDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Xin ZhouDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Carolyn GuanPrinceton University, Princeton, New Jersey 08544, USA.
Jeffery AckroydDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Shan JiangInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Jianhua ZhangDepartment of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Denise J SpringDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Y Alan WangDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Ronald A DePinhoDepartment of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
The University of Texas MD Anderson Cancer Center · USPrinceton University · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MThe RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7MDeveloping Novel Therapeutic Approaches Targeting Macrophages in GBMR01CA231349 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WANG, Y. ALAN · 2019 to 2024
$1.8MNCI NIH HHS P01 CA117969NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA231349
Abstract
The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases. Cancer genomic analysis identified frequent amplification of
Indexed as
AnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceNeoplastic Stem CellsPancreatic NeoplasmsT Cell Transcription Factor 1UbiquitinationUbiquitin ThiolesteraseWnt Signaling PathwayT Cell Transcription Factor 1TCF7 protein, humanUbiquitin ThiolesteraseUSP21 protein, humancancer stemnessdeubiquitinasepancreatic cancerTCF7USP21Wnt pathway
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.