Evidence map›Paper›PMID 31488579›Full record

ArticleGenes & development2019

Dustin L Gable, Valeriya Gaysinskaya, Christine C Atik, C Conover Talbot, Byunghak Kang, Susan E Stanley, Elizabeth W Pugh, Nuria Amat-Codina, Kara M Schenk, Murat O Arcasoy and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Review
  5. Review
  6. Clonal Signatures of Telomere Biology Disorders.Current hematologic malignancy reports · 2026
    Review
  7. Biogenesis and Regulation of Telomerase during Development and Cancer.Cold Spring Harbor perspectives in biology · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Genetic Familial Interstitial Lung Disease.Clinics in chest medicine · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Dustin L GableMedical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Valeriya GaysinskayaDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Christine C AtikDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
C Conover TalbotInstitute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Byunghak KangDepartment of Comparative and Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Susan E StanleyMedical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Elizabeth W PughDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Nuria Amat-CodinaDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Kara M SchenkOsler Medical Housestaff Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Murat O ArcasoyDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina 27708, USA.
Cory BraytonDepartment of Comparative and Molecular Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Liliana FloreaDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Mary ArmaniosDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USDuke University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007534 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Nadia N Hansel, Larissa A. Shimoda · 1985 to 2026
$28.3M
Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6M
Mechanisms of Telomere-Induced EmphysemaR01HL119476 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ARMANIOS, MARY Y · 2014 to 2023
$4.5M
Cancer Genetics of Short Telomere SyndromesR01CA225027 · NCI · JOHNS HOPKINS UNIVERSITY · PI ARMANIOS, MARY Y · 2018 to 2022
$2.4M
Mechanisms of telomerase RNA insufficiency in familial pulmonary fibrosisF32HL142207 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GAYSINSKAYA, VALERIYA A · 2018 to 2018
$59k
NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA225027NHLBI NIH HHS F32 HL142207NHLBI NIH HHS R01 HL119476NHLBI NIH HHS T32 HL007534NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM007814
6 · The paper itself

Abstract

Short telomere syndromes manifest as familial idiopathic pulmonary fibrosis; they are the most common premature aging disorders. We used genome-wide linkage to identify heterozygous loss of function of

Indexed as

Loss of Function MutationAnimalsBrainCarrier ProteinsCell LineCiliaFemaleGenetic LinkageHCT116 CellsHumansIdiopathic Pulmonary FibrosisMaleMiceMice, KnockoutNeurodevelopmental DisordersNuclear ProteinsCarrier ProteinsNuclear ProteinsRNATelomerasetelomerase RNAZCCHC8 protein, humanciliopathylung diseasenuclear RNA exosomeRNA processingtelomerase RNA

Identifiers

PMID31488579
PMCPMC6771387
OpenAlexW2971525400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.