Evidence map›Paper›PMID 31488572›Full record

ArticlePlant physiology2019

Chemical Screening Pipeline for Identification of Specific Plant Autophagy Modulators.

Adrian N Dauphinee, Catarina Cardoso, Kerstin Dalman, Jonas A Ohlsson, Stina Berglund Fick, Stéphanie Robert, Glenn R Hicks, Peter V Bozhkov, Elena A Minina

Open access · greenAbstract read
In one paragraph

Article in Plant physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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  5. Interactome ofInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Adrian N DauphineeDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala SE-750 07, Sweden.ORCID 0000-0002-3363-198X
Catarina CardosoDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala SE-750 07, Sweden.ORCID 0000-0003-3323-4447
Kerstin DalmanDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala SE-750 07, Sweden.ORCID 0000-0002-9919-9149
Jonas A OhlssonDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala SE-750 07, Sweden.ORCID 0000-0001-8598-2899
Stina Berglund FickChemical Biology Consortium Sweden, Umeå University, 901 87 Umea, Sweden.ORCID 0000-0003-4968-8830
Stéphanie RobertDepartment of Forest Genetics and Plant Physiology, Umeå Plant Science Centre, Swedish University of Agricultural Sciences, 901 83 Umea, Sweden.ORCID 0000-0002-0013-3239
Glenn R HicksCenter for Plant Cell Biology and Department of Botany and Plant Sciences, University of California, Riverside, California, 92521.ORCID 0000-0002-2502-7782
Peter V BozhkovDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala SE-750 07, Sweden.ORCID 0000-0002-8819-3884
Elena A MininaDepartment of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala SE-750 07, Sweden alena.minina@slu.se.ORCID 0000-0002-2619-1859
Swedish University of Agricultural Sciences · SEHeidelberg University · DEUmeå University · SEUniversity of California, Riverside · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is a major catabolic process in eukaryotes with a key role in homeostasis, programmed cell death, and aging. In plants, autophagy is also known to regulate agronomically important traits such as stress resistance, longevity, vegetative biomass, and seed yield. Despite its significance, there is still a shortage of reliable tools modulating plant autophagy. Here, we describe the first robust pipeline for identification of specific plant autophagy-modulating compounds. Our screening protocol comprises four phases: (1) high-throughput screening of chemical compounds in cell cultures of tobacco (

Indexed as

ArabidopsisAutophagyCell SurvivalDrug Evaluation, PreclinicalMacrolidesMorpholinesNicotianaOrganic ChemicalsThiadiazoles(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanolbenzo-1,2,3-thiadiazoleconcanamycin AMacrolidesMorpholinesOrganic ChemicalsThiadiazoles

Identifiers

PMID31488572
PMCPMC6836817
OpenAlexW2971778440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.