Evidence map›Paper›PMID 31488560›Full record

SynthesisHaematologica2020

Efficacy of central nervous system prophylaxis with stand-alone intrathecal chemotherapy in diffuse large B-cell lymphoma patients treated with anthracycline-based chemotherapy in the rituximab era: a systematic review.

Toby A Eyre, Faouzi Djebbari, Amy A Kirkwood, Graham P Collins

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Review
  14. Plasmablastic Lymphoma. A State-of-the-Art Review: Part 2-Focus on Therapy.Mediterranean journal of hematology and infectious diseases · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. CNS prophylaxis in aggressive B-cell lymphoma.Hematology. American Society of Hematology. Education Program · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Toby A EyreDepartment of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford toby.eyre@ouh.nhs.uk.
Faouzi DjebbariDepartment of Pharmacy, Oxford University Hospitals NHS Foundation Trust, Oxford.
Amy A KirkwoodCancer Research UK & UCL Cancer Trials Centre, UCL Cancer Institute, London, UK.
Graham P CollinsDepartment of Clinical Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford.
Oxford University Hospitals NHS Trust · GBCancer Research UK · GB

Funding

Department of Health
6 · The paper itself

Abstract

Central nervous system (CNS) relapse of diffuse large B-cell lymphoma remains uncommon but catastrophic. The benefit of standalone intrathecal prophylaxis in reducing CNS recurrence is unclear and remains controversial. No systematic review analysing the evidence for stand-alone intrathecal prophylaxis has been performed in the era of anti-CD20 monoclonal antibody therapy. A comprehensive search (01/2002-01/2019) was systematically performed using Ovid MEDLINE

Indexed as

Central Nervous System NeoplasmsLymphoma, Large B-Cell, DiffuseAnthracyclinesAntineoplastic Combined Chemotherapy ProtocolsCentral Nervous SystemCyclophosphamideDoxorubicinHumansNeoplasm Recurrence, LocalPrednisoneRetrospective StudiesRituximabVincristineAnthracyclinesCyclophosphamideDoxorubicinPrednisoneRituximabVincristine

Identifiers

PMID31488560
PMCPMC7327624
OpenAlexW2971529736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.