Evidence map›Paper›PMID 31488552›Full record

ArticleeNeuro

Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord.

Brian T David, Jessica J Curtin, David C Goldberg, Kerri Scorpio, Veena Kandaswamy, Caitlin E Hill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brian T DavidBurke Neurological Institute, White Plains, NY 10605 caitlinhill@neuralsci.org brian_david@rush.edu.ORCID 0000-0001-8470-802X
Jessica J CurtinBurke Neurological Institute, White Plains, NY 10605.
David C GoldbergBurke Neurological Institute, White Plains, NY 10605.
Kerri ScorpioBurke Neurological Institute, White Plains, NY 10605.
Veena KandaswamyBurke Neurological Institute, White Plains, NY 10605.
Caitlin E HillBurke Neurological Institute, White Plains, NY 10605 caitlinhill@neuralsci.org brian_david@rush.edu.ORCID 0000-0002-7356-2843
Cornell University · US

Funding

Using transcription factors to enhance transplanted cell survival for SCI repairR01NS075375 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI HILL, CAITLIN ELIZABETH · 2014 to 2017
$2.0M
NINDS NIH HHS R01 NS075375
6 · The paper itself

Abstract

Cellular transplantation is in clinical testing for a number of central nervous system disorders, including spinal cord injury (SCI). One challenge is acute transplanted cell death. To prevent this death, there is a need to both establish when the death occurs and develop approaches to mitigate its effects. Here, using luciferase (luc) and green fluorescent protein (GFP) expressing Schwann cell (SC) transplants in the contused thoracic rat spinal cord 7 d postinjury, we establish via

Indexed as

Hydrogen PeroxideSpinal Cord InjuriesAnimalsCell SurvivalHypoxiaRatsHydrogen Peroxidecell survivalin vivo imagingSchwann cellsspinal cord injurytranscription factortransplant

Identifiers

PMID31488552
PMCPMC7215587
OpenAlexW2971817885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.