ArticleeNeuro
Automated Behavioral Experiments in Mice Reveal Periodic Cycles of Task Engagement within Circadian Rhythms.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the development and application of home cage monitoring in laboratory mice and rats.BMC biology · 2023Pooled it
- A standardized and reproducible behavioral framework to elicit multiple aspects of visual spatial attention in mice.Cell reports methods · 2026Article
- Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making.Research square · 2026Article
- Diurnal rhythms of choice: a novel state-dependent drift diffusion model uncovers time-dependent changes in rat decision making.bioRxiv : the preprint server for biology · 2026Article
- Mouse Bio-behavioral Phenotyping Using a Digital Homecage Framework for Long-timescale, High-resolution, and Multi-factor Data Collection and Analytics.Research square · 2026Article
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- A standardized and reproducible behavioral protocol to elicit visual spatial attention in mice.bioRxiv : the preprint server for biology · 2025Article
- Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
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- Automated head-fixation training system with high levels of animal participation in psychoacoustic tasks.PloS one · 2025Article
- Brief periods of visual deprivation in adults increase performance on auditory tasks.iScience · 2024Article
- Dark exposure reduces high-frequency hearing loss in C57BL/6J mice.bioRxiv : the preprint server for biology · 2024Article
- Long-term training alters response dynamics in the aging auditory cortex.Hearing research · 2024Article
- ReptiLearn: An automated home cage system for behavioral experiments in reptiles without human intervention.PLoS biology · 2024Article
- Challenges and advanced concepts for the assessment of learning and memory function in mice.Frontiers in behavioral neuroscience · 2023Review
- Early peripheral activity alters nascent subplate circuits in the auditory cortex.Science advances · 2021Article
Corrections and comments
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3 authors.
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Abstract
High-throughput automated experiments accelerate discovery in neuroscience research and reduce bias. To enable high-throughput behavioral experiments, we developed a user-friendly and scalable automated system that can simultaneously train hundreds of mice on behavioral tasks, with time-stamped behavioral information recorded continuously for weeks. We trained 12 cages of C57BL/6J mice (24 mice, 2 mice/cage) to perform auditory behavioral tasks. We found that circadian rhythms modulated overall behavioral activity as expected for nocturnal animals. However, auditory detection and discrimination accuracy remained consistently high in both light and dark cycles. We also found a periodic modulation of behavioral response rates only during the discrimination task, suggesting that the mice periodically reduce task engagement (i.e., take "breaks") when task difficulty increases due to the more complex stimulus-response paradigm for discrimination versus detection. Our results highlight how automated systems for continuous high-throughput behavioral experiments enable both efficient data collection and new observations on animal behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.