ArticleGenetics2019
Comparison of the Full Distribution of Fitness Effects of New Amino Acid Mutations Across Great Apes.
Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 65 citations in OpenAlex.
- Gene-level complexity explains genome-wide variation in the distribution of fitness effects.Molecular biology and evolution · 2026Article
- The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals.PLoS biology · 2026Article
- Nucleotide diversity is a poor predictor of short-term adaptive potential.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Levels of additive genetic variation vary substantially between species.PLoS biology · 2026Article
- Inferring Patterns of Purifying, Positive, and Balancing Selection in the Coppery Titi Monkey (Plecturocebus cupreus) Utilizing a Well-Fit Evolutionary Baseline Model.Genome biology and evolution · 2026Article
- Empirical Validation of the Nearly Neutral Theory at Divergence and Population-Genomic Scales Using 144 Placental Mammal Genomes.Genome biology and evolution · 2026Article
- EMPIRICAL VALIDATION OF THE NEARLY NEUTRAL THEORY AT DIVERGENCE AND POPULATION GENOMIC SCALE USING 144 PLACENTAL MAMMALS GENOMES.bioRxiv : the preprint server for biology · 2026Article
- The impact of non-neutral synonymous mutations when inferring selection on nonsynonymous mutations.Genetics · 2025Article
- Recent Insights Into the Evolutionary Genomics of the Critically Endangered Aye-Aye (Daubentonia madagascariensis).American journal of primatology · 2025Review
- Article
- Accessible, Realistic Genome Simulation with Selection Using stdpopsim.Molecular biology and evolution · 2025Article
- SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution.bioRxiv : the preprint server for biology · 2025Article
- Accessible, realistic genome simulation with selection using stdpopsim.bioRxiv : the preprint server for biology · 2025Article
- Evolution of GC-biased gene conversion by natural selection.Genetics · 2025Article
- Whole-genome duplication increases genetic diversity and load in outcrossingProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Estimating the Distribution of Fitness Effects in Aye-Ayes (Daubentonia madagascariensis), Accounting for Population History as Well as Mutation and Recombination Rate Heterogeneity.American journal of primatology · 2025Article
- Detection of domestication signals through the analysis of the full distribution of fitness effects.Peer community journal · 2025Article
- Evolutionary consequences of domestication on the selective effects of new amino acid changing mutations in canids.bioRxiv : the preprint server for biology · 2024Article
- Revisiting Dominance in Population Genetics.Genome biology and evolution · 2024Review
- Biases in ARG-Based Inference of Historical Population Size in Populations Experiencing Selection.Molecular biology and evolution · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of fitness effects (DFE) is central to many questions in evolutionary biology. However, little is known about the differences in DFE between closely related species. We use >9000 coding genes orthologous one-to-one across great apes, gibbons, and macaques to assess the stability of the DFE across great apes. We use the unfolded site frequency spectrum of polymorphic mutations (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.