Evidence map›Paper›PMID 31488494›Full record

ArticleBMJ open2019

Neonatal azithromycin administration to prevent infant mortality: study protocol for a randomised controlled trial.

Ali Sie, Mamadou Bountogo, Eric Nebie, Mamadou Ouattara, Boubacar Coulibaly, Cheik Bagagnan, Pascal Zabre, Elodie Lebas, Jessica Brogdon, William W Godwin and 6 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03682653 (Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03682653 phase4completednot on this map

Neonates and Azithromycin, an Innovation in the Treatment of Children in Burkina Faso

TypeinterventionalSponsorUniversity of California, San FranciscoRan2019 to 2022Enrolled21,832ConditionsChildhood MortalityArmsAzithromycin, Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  8. Associations between Antenatal Care Visit Attendance and Infant Mortality and Growth.The American journal of tropical medicine and hygiene · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 2 countries.

Ali SieCentre de Recherche en Sante de Nouna, Nouna, Burkina Faso.
Mamadou BountogoCentre de Recherche en Sante de Nouna, Nouna, Burkina Faso.
Eric NebieCentre de Recherche en Sante de Nouna, Nouna, Burkina Faso.
Mamadou OuattaraCentre de Recherche en Sante de Nouna, Nouna, Burkina Faso.
Boubacar CoulibalyCentre de Recherche en Sante de Nouna, Nouna, Burkina Faso.
Cheik BagagnanCentre de Recherche en Sante de Nouna, Nouna, Burkina Faso.
Pascal ZabreCentre de Recherche en Sante de Nouna, Nouna, Burkina Faso.
Elodie LebasFrancis I Proctor Foundation, University of California, San Francisco, California, USA.
Jessica BrogdonFrancis I Proctor Foundation, University of California, San Francisco, California, USA.
William W GodwinFrancis I Proctor Foundation, University of California, San Francisco, California, USA.
Ying LinFrancis I Proctor Foundation, University of California, San Francisco, California, USA.
Travis PorcoFrancis I Proctor Foundation, University of California, San Francisco, California, USA.
Thuy DoanFrancis I Proctor Foundation, University of California, San Francisco, California, USA.
Thomas M LietmanFrancis I Proctor Foundation, University of California, San Francisco, California, USA.
Catherine E OldenburgFrancis I Proctor Foundation, University of California, San Francisco, California, USA catherine.oldenburg@ucsf.edu.ORCID 0000-0002-0763-399X
NAITRE Study Group
University of California, San Francisco · USCentre de Recherche en Santé de Nouna · BF

Funding

The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

introductionBiannual mass azithromycin distribution to children aged 1-59 months has been shown to reduce all-cause mortality. Children under 28 days of age were not treated in studies evaluating mass azithromycin distribution for child mortality due to concerns related to infantile hypertrophic pyloric stenosis (IHPS). Here, we report the design of a randomised controlled trial to evaluate the efficacy and safety of administration of a single dose of oral azithromycin during the neonatal period. METHODS AND ANALYSIS: The ETHICS AND DISSEMINATION: This study was approved by the Institutional Review Boards at the University of California, San Francisco in San Francisco, USA (Protocol #18-25027) and the Comité National d'Ethique pour la Recherche in Ouagadougou, Burkina Faso (Protocol #2018-10-123). The findings of this trial will be presented at local, regional and international meetings and published in open access peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03682653; Pre-results.

Indexed as

Infant MortalityAnti-Bacterial AgentsAzithromycinBody SizeBody WeightChild DevelopmentDouble-Blind MethodHumansInfantInfant, NewbornRandomized Controlled Trials as TopicAnti-Bacterial AgentsAzithromycinazithromycinneonatal mortalityrandomised controlled trialsub-Saharan Africa

Identifiers

PMID31488494
PMCPMC6731835
OpenAlexW2971612303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.