Evidence map›Paper›PMID 31488492›Full record

ArticleBMJ open2019

Zoledronate in the prevention of Paget's (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent

Owen Cronin, Laura Forsyth, Kirsteen Goodman, Steff C Lewis, Catriona Keerie, Allan Walker, Mary Porteous, Roseanne Cetnarskyj, Lakshminarayan R Ranganath, Peter L Selby and 32 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Updates on Paget's Disease of Bone.Endocrinology and metabolism (Seoul, Korea) · 2022
    Article
  4. Review
  5. Update on the pathogenesis and genetics of Paget's disease of bone.Frontiers in cell and developmental biology · 2022
    Review
  6. Genetic Determinants of Paget's Disease of Bone.Current osteoporosis reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 9 countries.

Owen CroninDepartment of Rheumatology, Western General Hospital, Edinburgh, UK.ORCID 0000-0002-1365-9942
Laura ForsythEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Kirsteen GoodmanGlasgow Caledonian University School of Nursing Midwifery and Community Health, Glasgow, UK.
Steff C LewisEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Catriona KeerieEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Allan WalkerEdinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK.
Mary PorteousMRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Roseanne CetnarskyjUniversity of Dundee - Fife Campus, Kirkcaldy, UK.
Lakshminarayan R RanganathUniversity of Liverpool, Liverpool, UK.
Peter L SelbyUniversity of Manchester, Manchester, UK.
Geeta HampsonGuy's and St Thomas' NHS Trust, London, UK.
Rama ChandraKing's College Hospital, London, UK.
Shu HoRobert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust, Oswestry, UK.
Jon H TobiasMusculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Steven Young-MinPortsmouth Hospitals NHS Trust, Portsmouth, UK.
Malachi J McKennaUniversity College Dublin, Dublin, Ireland.
Rachel K CrowleyUniversity College Dublin, Dublin, Ireland.
William D FraserDepartment of Medicine Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Luigi GennariUniversity of Siena Faculty of Medicine and Surgery, Siena, Italy.
Ranuccio NutiUniversity of Siena Faculty of Medicine and Surgery, Siena, Italy.
Maria Luisa BrandiUniversity Hospital Careggi, Firenze, Italy.
Javier Del Pino-MontesUniversity Hospital of Salamanca, Salamanca, Spain.
Jean-Pierre DevogelaerCliniques Universitaires Saint-Luc, Bruxelles, Belgium.
Anne DurnezRheumatology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.
Giancarlo IsaiaUniversità degli Studi di Torino, Torino, Piemonte, Italy.
Marco Di StefanoUniversità degli Studi di Torino, Torino, Piemonte, Italy.
Núria GuañabensRheumatology Department, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.
Josep BlanchHospital del Mar, Barcelona, Catalunya, Spain.
Markus J SeibelConcord Repatriation General Hospital, Sydney, New South Wales, Australia.
John P WalshDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Mark A KotowiczDepartment of Endocrinology and Diabetes, Barwon Health, Geelong, Victoria, Australia.
Geoffrey C NicholsonRural Clinical School, University of Queensland, Toowoomba, Queensland, Australia.
Emma L DuncanDepartment of Endocrinology and Diabetes, Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.
Gabor MajorRoyal Newcastle Centre John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia.
Anne HorneDepartment of Medicine, University of Auckland, Auckland, New Zealand.
Nigel L GilchristGCM Research Trust, Burnwood Hospital, Christchurch, New Zealand.
Maarten BoersEpidemiology & Biostatistics, Amsterdam Rheumatology and Immunology Center, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands.
Gordon D MurrayUsher Institute, University of Edinburgh, Edinburgh, United Kingdom.
Keith CharnockThe Paget's Association, Manchester, UK.
Diana WilkinsonThe Paget's Association, Manchester, UK.
R Graham G RussellMellanby Centre for Bone Research, University of Sheffield, Sheffield, UK.
Stuart H RalstonMRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK stuart.ralston@ed.ac.uk.
Clinical Research Institute · USCliniques Universitaires Saint-Luc · BEInstitute of Genetics and Cancer · GBPress Association · GBUniversity College Dublin · IEUniversity of Siena · ITUniversity of Turin · ITAmsterdam University Medical Centers · NLAzienda Ospedaliero-Universitaria Careggi · ITBarwon Health · AUGlasgow Caledonian University · GBGuy's and St Thomas' NHS Foundation Trust · GBHospital Clínic de Barcelona · ESHospital Del Mar · ESJohn Hunter Hospital · AUKing's College Hospital · GBPortsmouth Hospitals NHS Trust · GBQueensland University of Technology · AURobert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust · GBThe University of Queensland · AU

Funding

Arthritis Research UK 18163Medical Research Council 85281Versus Arthritis 18163
6 · The paper itself

Abstract

introductionPaget's disease of bone (PDB) is characterised by increased and disorganised bone remodelling affecting one or more skeletal sites. Complications include bone pain, deformity, deafness and pathological fractures. Mutations in sequestosome-1 ( METHODS AND ANALYSIS: People with a family history of PDB aged >30 years who test positive for ETHICS AND DISSEMINATION: The study was approved by the Fife and Forth Valley Research Ethics Committee on 22 December 2008 (08/S0501/84). Following completion of the trial, a manuscript will be submitted to a peer-reviewed journal. The results of this trial will inform clinical practice by determining if early intervention with ZA in presymptomatic individuals with TRIAL REGISTRATION NUMBER: ISRCTN11616770.

Indexed as

AdultAnxietyBone Density Conservation AgentsDepressionGenetic TestingHumansMusculoskeletal PainMutationOsteitis DeformansQuality of LifeRadionuclide ImagingRandomized Controlled Trials as TopicSequestosome-1 ProteinZoledronic AcidBone Density Conservation AgentsSequestosome-1 ProteinSQSTM1 protein, humanZoledronic AcidbisphosphonatePaget’s Disease of Bonerandomized controlled trialSQSTM1, geneticsZoledronic acid

Identifiers

PMID31488492
PMCPMC6731944
OpenAlexW2971692439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.