Evidence map›Paper›PMID 31487846›Full record

ArticleBrain sciences2019

A Comprehensive Examination of Percutaneous Endoscopic Gastrostomy and Its Association with Amyotrophic Lateral Sclerosis Patient Outcomes.

Leila Bond, Paulamy Ganguly, Nishad Khamankar, Nolan Mallet, Gloria Bowen, Braden Green, Cassie S Mitchell

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06609213 narecruitingnot on this mapstarted 2025, after this paper: background citation

Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via G-Tube and Its Impact on Formula Intolerance in pALS

TypeinterventionalSponsorAndrea CharvetRan2025 to 2026Enrolled22ConditionsAmyotrophic Lateral Sclerosis, Gastrointestinal Intolerance, Enteral Nutrition TherapyArmsMedical Food
NCT07233148 recruitingnot on this mapstarted 2026, after this paper: background citation

Healing ALS Registry Observational Study (HAROS)

Typeobservational_patient_registrySponsorHealing Advocates Registry and MinistryRan2026 to 2036Enrolled1,000ConditionsAmyotrophic Lateral Sclerosis (ALS), Motor Neuron Disease (MND), Primary Lateral Sclerosis (PLS)ArmsEducation about treatment options, Dietary Supplements: Vitamins, Minerals, Herbs, etc., Meditation, Prayer, Talk Therapy, Affirmations, Journaling, etc., Diet, various diets will be observed, Exercise, physical therapy, occupational therapy, speech therapy, sauna, EMS, massage and other therapies
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A prospective observational study of decision-making by patients with amyotrophic lateral sclerosis upon recommendation for PEG enteral feeding tubes.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Enteral tube feeding for amyotrophic lateral sclerosis/motor neuron disease.The Cochrane database of systematic reviews · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Leila BondLaboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Paulamy GangulyLaboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Nishad KhamankarLaboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Nolan MalletLaboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Gloria BowenLaboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Braden GreenLaboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA.
Cassie S MitchellLaboratory for Pathology Dynamics, Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332, USA. cassie.mitchell@bme.gatech.edu.
Emory University · USGeorgia Institute of Technology · US

Funding

Identification of Amyotrophic Lateral Sclerosis Clinical PredictorsR21NS081426 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI MITCHELL, CASSIE S · 2013 to 2014
$389k
Optimization of Bi-Pap and PEG intervention protocols for Amyotrophic Lateral SclerosisR03NS098228 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI MITCHELL, CASSIE S · 2016 to 2017
$158k
NIH HHS NS098228NINDS NIH HHS R03 NS098228NINDS NIH HHS R21 NS081426
6 · The paper itself

Abstract

There is literature discord regarding the impact of percutaneous endoscopic gastrostomy (PEG), or "feeding tube", on amyotrophic lateral sclerosis (ALS) outcomes. We assess one of the largest retrospective ALS cohorts to date (278 PEG users, 679 non-users). Kruskal-Wallis and Kaplan-Meier analysis compared cohort medians and survival duration trends. A meta-analysis determined the aggregate associative effect of PEG on survival duration by combining primary results with 7 published studies. Primary results (

Indexed as

ALSdysphagiamalnutritionmotor neuron disease

Identifiers

PMID31487846
PMCPMC6770872
OpenAlexW2971387871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.