Evidence map›Paper›PMID 31487824›Full record

ArticleBiomolecules2019

New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities.

Marcin Cieślak, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, Mariola Napiórkowska, Iga Stukan, Urszula Wojda, Barbara Nawrot

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Protective Effect ofMolecules (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marcin CieślakCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Poland. marcin@cbmm.lodz.pl.ORCID 0000-0002-9628-214X
Julia Kaźmierczak-BarańskaCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Poland.
Karolina Królewska-GolińskaCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Poland.
Mariola NapiórkowskaDepartment of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland.ORCID 0000-0002-1174-2208
Iga StukanLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Urszula WojdaLaboratory of Preclinical Testing of Higher Standard, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Barbara NawrotCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Poland.ORCID 0000-0002-4084-4334
Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk · PLInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLMedical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We identified novel dicarboximides that were selectively cytotoxic towards human leukemia cells. Using chemical and biological methods, we characterized the biological activity, identified cellular protein targets and defined the mechanism of action of the test dicarboximides. The reported IC

Indexed as

Antineoplastic AgentsApoptosisATP-Binding Cassette TransportersCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansImmunologic FactorsK562 CellsMolecular StructureStructure-Activity RelationshipThalidomideTumor Cells, CulturedABCF1 protein, humanAntineoplastic AgentsATP-Binding Cassette TransportersImmunologic FactorsThalidomideABC50 (ABCf1)anticancer compoundsapoptosiscytotoxicitydicarboximidesleukemiaprotac (proteolysis targeting chimera)

Identifiers

PMID31487824
PMCPMC6770581
OpenAlexW2971551277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.