Evidence map›Paper›PMID 31487503›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2019

LDL receptor related protein 1 requires the I

Joslyn Mills, Toshihiko Hanada, Yoichi Hase, Laura Liscum, Athar H Chishti

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. KIF13B mediates VEGFR2 recycling to modulate vascular permeability.Cellular and molecular life sciences : CMLS · 2023
    Article
  10. Kinesins in Mammalian Spermatogenesis and Germ Cell Transport.Frontiers in cell and developmental biology · 2022
    Review
  11. KIF13A-A Key Regulator of Recycling Endosome Dynamics.Frontiers in cell and developmental biology · 2022
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joslyn MillsGraduate Program in Cellular and Molecular Physiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.
Toshihiko HanadaDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
Yoichi HaseDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
Laura LiscumGraduate Program in Cellular and Molecular Physiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA; Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.
Athar H ChishtiGraduate Program in Cellular and Molecular Physiology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA. Electronic address: athar.chishti@tufts.edu.
Tufts University · US

Funding

UCD KOMP PROJECT REPOSITORYU42RR024244 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2007 to 2010
$7.9M
Role of erythrocyte band 3 in malaria adhesionR01HL060961 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHISHTI, ATHAR H. · 1998 to 2023
$5.9M
FUNCTIONAL STUDIES OF RED BLOOD CELL DEMATINR01HL051445 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHISHTI, ATHAR H. · 1994 to 2010
$1.9M
Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1R01HL095050 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHISHTI, ATHAR H. · 2009 to 2012
$1.6M
Calpain-1 Signaling Pathways in PlateletsR01HL089517 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHISHTI, ATHAR H. · 2009 to 2012
$1.6M
Functional Studies of Erythrocyte DematinR56HL051445 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHISHTI, ATHAR H. · 2008 to 2008
$393k
NCRR NIH HHS U42 RR024244NHLBI NIH HHS R01 HL051445NHLBI NIH HHS R01 HL060961NHLBI NIH HHS R01 HL089517NHLBI NIH HHS R01 HL095050NHLBI NIH HHS R56 HL051445
6 · The paper itself

Abstract

KIF13B, a kinesin-3 family motor, was originally identified as GAKIN due to its biochemical interaction with human homolog of Drosophila discs-large tumor suppressor (hDLG1). Unlike its homolog KIF13A, KIF13B contains a carboxyl-terminal CAP-Gly domain. To investigate the function of the CAP-Gly domain, we developed a mouse model that expresses a truncated form of KIF13B protein lacking its CAP-Gly domain (KIF13BΔCG), whereas a second mouse model lacks the full-length KIF13A. Here we show that the KIF13BΔCG mice exhibit relatively higher serum cholesterol consistent with the reduced uptake of [

Indexed as

AnimalsCells, CulturedDiscs Large Homolog 1 ProteinKinesinsLow Density Lipoprotein Receptor-Related Protein-1Membrane ProteinsMiceMice, Inbred C57BLMice, KnockoutDiscs Large Homolog 1 ProteinDlg1 protein, mouseKIF13b protein, mouseKinesinsLow Density Lipoprotein Receptor-Related Protein-1Membrane ProteinsCholesterolDLG1EndocytosisGAKINKIF13AKIF13BKinesinLRP1Molecular motorProtein-protein interaction

Identifiers

PMID31487503
PMCPMC6851494
OpenAlexW2971853832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.