Evidence map›Paper›PMID 31487433›Full record

ArticleNeuropsychopharmacology reports2019

Brexpiprazole has a low risk of dopamine D

Naoki Amada, Hitomi Akazawa, Yuta Ohgi, Kenji Maeda, Haruhiko Sugino, Nobuyuki Kurahashi, Tetsuro Kikuchi, Takashi Futamura

Open access · goldAbstract read
In one paragraph

Article in Neuropsychopharmacology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Brexpiprazole for the Treatment of Agitation Associated with Dementia due to Alzheimer's Disease: Clinical Perspectives.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Review
  2. Dopamine DPsychological medicine · 2025
    Article
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  14. Brexpiprazole has a low risk of dopamine DNeuropsychopharmacology reports · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Naoki AmadaDepartment of CNS Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.ORCID 0000-0002-9625-6240
Hitomi AkazawaDepartment of CNS Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
Yuta OhgiDepartment of CNS Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
Kenji MaedaDepartment of Lead Discovery Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
Haruhiko SuginoGlobal Business Development, Otsuka Pharmaceutical Development and Commercialization, Ltd., Princeton, New Jersey.
Nobuyuki KurahashiGlobal CNS Business, Otsuka Pharmaceutical Development and Commercialization, Ltd., Princeton, New Jersey.
Tetsuro KikuchiPharmaceutical Division, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
Takashi FutamuraDepartment of CNS Research, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.
Otsuka (Japan) · JPOtsuka (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong-term antipsychotic treatment in patients with schizophrenia can induce supersensitivity psychosis and tardive dyskinesia which is thought to be caused by dopamine D

methodsThe maximum D

resultsHaloperidol and brexpiprazole (30 mg/kg: approximately tenfold ED

conclusionBrexpiprazole has a low risk of D

Indexed as

AnimalsAntipsychotic AgentsApomorphineDopamine AgonistsDyskinesia, Drug-InducedHaloperidolQuinolonesRatsReceptors, Dopamine D2Receptor, Serotonin, 5-HT2AStereotyped BehaviorThiophenesAntipsychotic AgentsApomorphinebrexpiprazoleDopamine AgonistsHaloperidolQuinolonesReceptors, Dopamine D2Receptor, Serotonin, 5-HT2AThiophenesantipsychotic drugbrexpiprazoleD2 receptor partial agonistrebound symptomsreceptor sensitization

Identifiers

PMID31487433
PMCPMC7292306
OpenAlexW2971375204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.