ArticleJournal of molecular evolution
Domain organization and intron positions in Caenorhabditis elegans collagen genes: the 54-bp module hypothesis revisited.
Article in Journal of molecular evolution. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Cloning and chromosomal location of human alpha 1(XVI) collagen.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Characterization of a fibrillar collagen gene in sponges reveals the early evolutionary appearance of two collagen gene families.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Evolution of collagen IV genes from a 54-base pair exon: a role for introns in gene evolution.Journal of molecular evolution · 1990Article
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1 author at 1 institution in 1 country.
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Abstract
The amino acid (aa) sequences of the polypeptides encoded by five collagen genes of the nematode Caenorhabditis elegans, col-6, col-7 (partial), col-8, col-14, and col-19, were determined. These collagen polypeptides, as well as those encoded by the previously sequenced C. elegans collagen genes col-1 and col-2, share a common organization into five domains: an amino-terminal leader, a short (30-33 aa) (Gly-X-Y)n domain, a non(Gly-X-Y) spacer, a long (127-132 aa) (Gly-X-Y)n domain, and a short carboxyl-terminal domain. The domain organizations and intron positions of these polypeptides were compared with those of the polypeptides encoded by Drosophila and Strongylocentrotus type IV, and vertebrate types I, II, III, IV, and IX collagen genes; the C. elegans collagen polypeptides are most similar to the vertebrate type IX collagens. It is suggested that the collagen gene family comprises two divergent subfamilies, one of which includes the vertebrate interstitial collagen genes, and the other of which includes the invertebrate collagen genes and the vertebrate type IV and type IX collagen genes. Only the vertebrate interstitial collagen genes display clear evidence of evolution via the tandem duplication of a 54-bp exon.
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