ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2019
Trophoblasts promote induction of a regulatory phenotype in B cells that can protect against detrimental T cell-mediated inflammation.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Type I Interferon Regulation of HLA-F Expression in Human Trophoblasts During Viral Infection.Viruses · 2026Article
- The modeling of human implantation and early placentation: achievements and perspectives.Human reproduction update · 2025Review
- B Cell Responses to the Placenta and Fetus.Annual review of pathology · 2025Review
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- Article
- TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion.Frontiers in immunology · 2021Article
- Memory B Cells in Pregnancy Sensitization.Frontiers in immunology · 2021Review
- Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight.International journal of molecular sciences · 2020Review
- Uterine B Cells Exhibit Regulatory Properties During the Peri-Implantation Stage of Murine Pregnancy.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
problemA successful outcome to pregnancy is critically dependent on the initiation of maternal immune tolerance before embryo implantation. Cells of embryonic origin that come in contact with the uterine microenvironment can exert influence over the phenotype and function of immune cells to facilitate robust implantation; however, what influence they may have on B cells remains unknown. In this study, we investigate the effect of human trophoblast cells on B-cell phenotype and the subsequent effect on peri-implantation events. METHOD OF STUDY: We cultured purified human B cells with the first-trimester human trophoblast cell line Swan 71 to investigate trophoblast-B-cell interactions and utilized trophoblast spheroids in an in vitro implantation model of migration and invasion.
resultsTrophoblast-educated B cells or TE-B cells were found to consist of B cells in committed lineages such as plasmablasts and memory B cells, as well as increased proportions in subsets of CD24
conclusionWe posit that trophoblast-mediated education of B cells leads to their acquisition of properties capable of modulating inflammation in the uterine environment during the peri-implantation period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.