Evidence map›Paper›PMID 31487226›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2019

The effects of moderate and high-intensity exercise on circulating markers of endothelial integrity and activation in young, healthy men.

Ryan M Sapp, William S Evans, Lauren E Eagan, Catalina A Chesney, Evelyn M Zietowski, Steven J Prior, Sushant M Ranadive, James M Hagberg

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Exercise and Circulating Microparticles in Healthy Subjects.Journal of cardiovascular translational research · 2021
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Article
  8. Article
  9. miR-126: a bridge between cancer and exercise.Cancer cell international · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Hypoxia briefly increases diuresis but reduces plasma volume by fluid redistribution in women.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryan M SappDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.
William S EvansDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.
Lauren E EaganDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.
Catalina A ChesneyDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.
Evelyn M ZietowskiDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.
Steven J PriorDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.ORCID 0000-0002-4627-6489
Sushant M RanadiveDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.
James M HagbergDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland.

Funding

University of MD Aging, Diversity, and Professional Training (ADAPT) ProgramR25AG045063 · NIA · UNIV OF MARYLAND, COLLEGE PARK · PI HAGBERG, JAMES M · 2013 to 2023
$2.6M
University of Maryland Summer Training and Research (UM STAR) ProgramR25HL092604 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI HAGBERG, JAMES M · 2008 to 2024
$1.6M
NHLBI NIH HHS R25 HL092604NIA NIH HHS R25 AG045063
6 · The paper itself

Abstract

Endothelial function typically exhibits a hormetic response to exercise. It is unknown whether endothelial damage occurs in response to acute exercise and could be a contributing mechanism. We sought to determine the effects of acute exercise on endothelial-derived circulating factors proposed to reflect endothelial integrity and activation. Young, healthy men (

Indexed as

High-Intensity Interval TrainingAdultBiomarkersCell-Derived MicroparticlesEndothelial CellsEndothelium, VascularHumansMaleMicroRNAsSyndecan-1Thrombomodulinvon Willebrand FactorYoung AdultBiomarkersMicroRNAsSDC1 protein, humanSyndecan-1Thrombomodulinvon Willebrand FactorendotheliumexerciseglycocalyxmicroRNAmicrovesicles

Identifiers

PMID31487226
PMCPMC6879831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.