ArticleEnvironmental health perspectives2019
Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China.
Article in Environmental health perspectives, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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36 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Relationship between household air pollution and lung cancer in never smokers in high-income countries: a systematic review.BMJ open · 2025Pooled it
- Variation on Toxic and Inflammatory Potential of Coal Smoke of Different Sources From a Region With High Lung Cancer Risk.Environmental toxicology · 2026Article
- [China Wumeng Mountain Lung Cancer: Evidence Chain, Clinical and Molecular Characteristics of Regional Lung Cancer Related to Coal Pollution in the Yunnan-Guizhou Plateau].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Review
- Indoor Air Pollution and Lung Cancer Risk-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- ACSM5 c.1273 C> A Polymorphism Promotes Malignant Progression of Lung Adenocarcinoma in Xuanwei Region.Applied biochemistry and biotechnology · 2026Article
- Epidemiology of Lung Cancer in Saudi Arabia, Saudi Cancer Registry, 2015-2020.Journal of epidemiology and global health · 2025Article
- Exposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China.Environment international · 2025Article
- The Association Between Indoor Air Pollution and Lung Cancer Risk in a Chinese Population.Indoor air · 2025Article
- Reduction in polycyclic aromatic hydrocarbon exposure in Beijing following China's clean air actions.Science bulletin · 2024Article
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- Patterns and trends of mortality from metastatic colorectal cancer in Shanghai, China from 2005 to 2021: a population-based retrospective analysis.Journal of cancer research and clinical oncology · 2024Article
- Identification of core carcinogenic elements based on the age-standardized mortality rate of lung cancer in Xuanwei Formation coal in China.Scientific reports · 2024Article
- Distinct Genomic Landscape of Lung Adenocarcinoma from Household Use of Smoky Coal.American journal of respiratory and critical care medicine · 2023Article
- Narrative review: respiratory tract microbiome and never smoking lung cancer.Journal of thoracic disease · 2023Review
- Genomic medicine and cancer clinical trial in Thailand.Cancer biology & medicine · 2023Article
- Exposure to smoky coal combustion emissions and leukocyte Alu retroelement copy number.Carcinogenesis · 2023Article
- Indoor wood-burning from stoves and fireplaces and incident lung cancer among Sister Study participants.Environment international · 2023Article
- Household air pollution and epigenetic aging in Xuanwei, China.Environment international · 2023Article
- Methylated polycyclic aromatic hydrocarbons from household coal use across the life course and risk of lung cancer in a large cohort of 42,420 subjects in Xuanwei, China.Environment international · 2023Article
- Lung cancer screening in the Philippines: the need for guidelines based on the local context and the imperative for improved access to screening.The Lancet regional health. Western Pacific · 2023Article
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22 authors at 9 institutions in 5 countries.
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Abstract
backgroundLung cancer rates among never-smoking women in Xuanwei and Fuyuan in China are among the highest in the world and have been attributed to the domestic use of smoky (bituminous) coal for heating and cooking. However, the key components of coal that drive lung cancer risk have not been identified.
objectivesWe aimed to investigate the relationship between lifelong exposure to the constituents of smoky coal (and other fuel types) and lung cancer.
methodsUsing a population-based case-control study of lung cancer among 1,015 never-smoking female cases and 485 controls, we examined the association between exposure to 43 household air pollutants and lung cancer. Pollutant predictions were derived from a comprehensive exposure assessment study, which included methylated polycyclic aromatic hydrocarbons (PAHs), which have never been directly evaluated in an epidemiological study of any cancer. Hierarchical clustering and penalized regression were applied in order to address high colinearity in exposure variables.
resultsThe strongest association with lung cancer was for a cluster of 25 PAHs [odds ratio (OR): 2.21; 95% confidence interval (CI): 1.67, 2.87 per 1 standard deviation (SD) change], within which 5-methylchrysene (5-MC), a mutagenic and carcinogenic PAH, had the highest individual observed OR (5.42; 95% CI: 0.94, 27.5). A positive association with nitrogen dioxide ([Formula: see text]) was also observed (OR: 2.06; 95% CI: 1.19, 3.49). By contrast, neither benzo(a)pyrene (BaP) nor fine particulate matter with aerodynamic diameter [Formula: see text] ([Formula: see text]) were associated with lung cancer in the multipollutant models.
conclusionsTo our knowledge, this is the first study to comprehensively evaluate the association between lung cancer and household air pollution (HAP) constituents estimated over the entire life course. Given the global ubiquity of coal use domestically for indoor cooking and heating and commercially for electric power generation, our study suggests that more extensive monitoring of coal combustion products, including methylated PAHs, may be warranted to more accurately assess health risks and develop prevention strategies from this exposure. https://doi.org/10.1289/EHP4913.
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