ReviewAging clinical and experimental research2021
Bloodstream infections in the elderly: what is the real goal?
Review in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
- ICD-10-CM-Based Algorithms to Identify Bacteremia Incorporating Pathogen-Specific Codes: A Validation Study.Pharmacoepidemiology and drug safety · 2026Article
- Early diagnostic value of serum procalcitonin, C-reactive protein, white blood cell count and the neutrophil percentage in bacterial and fungal bloodstream infections.BMC immunology · 2026Article
- Sepsis in Frail Older Adults: Tailored Antimicrobial Stewardship and Individualized Care Approach.Antibiotics (Basel, Switzerland) · 2026Review
- Monocyte Distribution Width as a Biomarker for Predicting Bacteremia: A Retrospective Study in the Emergency Department.Life (Basel, Switzerland) · 2026Article
- Nomogram-based analysis of plasma albumin and C-reactive protein 30 days before bloodstream infection for 30-day mortality in Singapore and Denmark.Scientific reports · 2026Article
- Neutrophil-Percentage-to-Albumin Ratio and Monocyte-to-Albumin Ratio: Utility of the Combined Biomarkers in the Prediction of 30-Day Mortality in Male Diabetes Patients Over 80 Years Old with Bloodstream Infections.Clinical interventions in aging · 2026Article
- Outcomes of Hospitalized Octogenarians withPathogens (Basel, Switzerland) · 2025Article
- The role of Geriatric Nutritional Risk Index in predicting adverse outcomes in patients with bloodstream infections: a retrospective study.BMC geriatrics · 2025Article
- Damage response signaling by the extracellular adenosine pathway: control of infection outcome during host aging.mSphere · 2025Review
- Empiric and targeted antibiotic therapy for bloodstream infections in internal medicine patients in Poland: a three-year analysis in a single centre using the AWaRe classification.Pharmacological reports : PR · 2025Article
- Clinical features and risk factors of older adults with bloodstream infection.BMC geriatrics · 2025Article
- Research and predictive analysis of the disease burden of bloodstream infectious diseases in China.BMC infectious diseases · 2025Article
- Antimicrobial susceptibility of gram-negative strains isolated from bloodstream infections in China: Results from the study for monitoring antimicrobial resistance trends (SMART) 2018-2020.Epidemiology and infection · 2025Article
- ddPCR Enhances early diagnosis, treatment, prognosis, and pathogen verification in elderly BSI.Frontiers in cellular and infection microbiology · 2025Article
- Low NAPR as a Novel Indicator for PredictingClinical interventions in aging · 2025Article
- A Mortality Prediction Nomogram forInfection and drug resistance · 2025Article
- Analysis of risk factors for poor prognosis in patients with renal insufficiency combined withPeerJ · 2025Article
- Innovations in Imaging:Current cardiology reports · 2024Review
- Observational
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bloodstream infections (BSI) represent a serious bacterial infection with substantial morbidity and mortality. Population-based studies demonstrate an increased incidence, especially among elderly patients. Controversy exists regarding whether presentation of BSI are different in older patients compared to younger patients; our narrative review of the literature suggests that BSI in elderly patients would probably include one or more of the traditional symptoms/signs of fever, severe sepsis or septic shock, acute kidney injury, and/or leukocytosis. Sources of BSI in older adults are most commonly the urinary tract (more so than in younger adults) and the respiratory tract. Gram-negative bacteria are the most common isolates in the old (~ 40-60% of BSI); isolates from the elderly patient population show higher antibiotic resistance rates, with long-term care facilities serving as reservoirs for multidrug-resistant bacteria. BSI entail significantly higher rates of mortality in older age, both short and long term. Some of the risk factors for mortality are modifiable, such as the appropriateness of empirical antibiotic therapy and nosocomial acquisition of infection. Health-related quality of life issues regarding the elderly patient with BSI are not well addressed in the literature. Utilization of comprehensive geriatric assessment and comprehensive geriatric discharge planning need to be investigated further in this setting and might serve as key for improved results in this population. In this review, we address all these aspects of BSI in old patients with emphasis on future goals for management and research.
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