Evidence map›Paper›PMID 31486876›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlative

M Unterrainer, D F Fleischmann, F Vettermann, V Ruf, L Kaiser, D Nelwan, S Lindner, M Brendel, V Wenter, S Stöcklein and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Review
  3. Tracking macrophages by direct and indirectEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  4. The confounding effects of microvascular physiology on the uptake and diagnostic accuracy of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Article
  6. Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH-Wild-Type Glioblastoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. TSPO PET signal using [European journal of nuclear medicine and molecular imaging · 2023
    Article
  18. Feasibility of radiomic feature harmonization for pooling of [Zeitschrift fur medizinische Physik · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

M UnterrainerDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
D F FleischmannGerman Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
F VettermannDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
V RufDepartment of Neuropathology, LMU Munich, Munich, Germany.
L KaiserDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
D NelwanDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
S LindnerDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
M BrendelDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
V WenterDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
S StöckleinDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
J HermsDepartment of Neuropathology, LMU Munich, Munich, Germany.
V M MilenkovicDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
R RupprechtDepartment of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
J C TonnGerman Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
C BelkaGerman Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
P BartensteinDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
M NiyaziGerman Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
N L AlbertDepartment of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany. nathalie.albert@med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DELMU Klinikum · DEGerman Cancer Research Center · DEHeidelberg University · DEUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 18-kDa translocator protein (TSPO) is overexpressed in brain tumours and represents an interesting target for glioma imaging.

methodsFifty-eight patients with histologically validated glioma at initial diagnosis or recurrence were included. All patients underwent

resultsSix of 58 patients presented with WHO grade II, 16/58 grade III and 36/58 grade IV gliomas. An (IDH) mutation was found in 19/58 cases, and 39/58 were classified as IDH-wild type. High

conclusionUptake characteristics on

Indexed as

Brain NeoplasmsGliomaCarbazolesHumansMolecular BiologyMutationNeoplasm GradingNeoplasm Recurrence, LocalPositron-Emission TomographyReceptors, GABACarbazolesGE-180Receptors, GABATSPO protein, human18F-GE-180GliomaGradingMolecular geneticsTSPO

Identifiers

PMID31486876
OpenAlexW2972170790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.