ArticleJournal of molecular evolution2019
Stress Adapted Mollusca and Nematoda Exhibit Convergently Expanded Hsp70 and AIG1 Gene Families.
Article in Journal of molecular evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The chromosome-level genome assembly of the slug Deroceras laeve facilitates its use as a comparative model of regeneration.G3 (Bethesda, Md.) · 2025Article
- Transcriptome sequencing of the endangered land snail Karaftohelix adamsi from the Island Ulleung: De novo assembly, annotation, valuation of fitness genes and SSR markers.Genes & genomics · 2024Article
- Expansion of the HSP70 gene family in Tegillarca granosa and expression profiles in response to zinc toxicity.Cell stress & chaperones · 2024Article
- Microbial ecology of the deep terrestrial subsurface.The ISME journal · 2024Review
- De novo genome assembly and genome skims reveal LTRs dominate the genome of a limestone endemic Mountainsnail (Oreohelix idahoensis).BMC genomics · 2022Article
- Detecting Selection on Segregating Gene Duplicates in a Population.Journal of molecular evolution · 2021Article
- Review
- Single individual structural variant detection uncovers widespread hemizygosity in molluscs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Article
- 2019 Zuckerkandl Prize.Journal of molecular evolution · 2020Article
- The genome of a subterrestrial nematode reveals adaptations to heat.Nature communications · 2019Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently sequenced the genome of the first subterrestrial metazoan, the nematode Halicephalobus mephisto. A central finding was a dramatic expansion of genes encoding avrRpt2 induced gene (AIG1), and 70 kDa heat shock (Hsp70) domains. While the role of Hsp70 in thermotolerance is well established, the contribution of AIG1 is much more poorly characterized, though in plants some members of this family are heat-induced. Hypothesizing that this dual domain expansion may constitute a general biosignature of thermal stress adaptation, here we examine a number of genomes, finding that expansion of both AIG1 and Hsp70 is common in bivalves. Phylogenetic analysis reveals that the bivalve-specific Hsp70 protein expansion groups with H. mephisto sequences. Our identification of the same gene expansions in bivalves and a nematode implies that this biosignature may be a general stress adaptation strategy for protostomes, particularly those organisms that cannot escape their stressful environments. We hypothesize that the two families play largely complementary mechanistic roles, with Hsp70 directly refolding heat-denatured proteins while AIG1 promotes cellular and organismal survival by inhibiting apoptosis.
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