ArticleInternational wound journal2019
Investigating the effect of age on platelet ultrastructure using transmission electron microscopy.
Article in International wound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Biological processes and factors involved in soft and hard tissue healing.Periodontology 2000 · 2025Review
- Article
- Whole-mount Electron Microscopy to Quantitate Platelet Dense Granules: Reference Intervals for Healthy Controls in Korea.Annals of laboratory medicine · 2023Article
- Platelets' Nanomechanics and Morphology in Neurodegenerative Pathologies.Biomedicines · 2022Article
- Hermansky-Pudlak syndrome type 2: A rare cause of severe periodontitis in adolescents-A case study.Frontiers in pediatrics · 2022Article
- Platelets in aging and cancer-"double-edged sword".Cancer metastasis reviews · 2020Review
- Use of electron microscopy to study platelets and thrombi.Platelets · 2020Review
- Factors associated with positive outcomes of platelet-rich plasma therapy in Achilles tendinopathy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Article
- Investigating the effect of age on platelet ultrastructure using transmission electron microscopy.International wound journal · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In the present study, the age- and sex-related differences in platelet ultrastructure were investigated using transmission electron microscopy (TEM). A total of 15 healthy volunteers were grouped according to age, with 5 people in each of the following groups: young group (25-45 years), middle-aged group (46-65 years), and old-aged group (> 65 years). In the TEM micrographs, the internal components, specifically the α-granules, dense granules, and lysosomal granules, of 20 platelets were counted for each group. Two-way analysis of variance of age and sex variance was used to compare the results. The ultrastructure of the platelets in the old-aged group was observed to be quite different from those of the young and middle-aged groups. Specifically, with ageing, the platelet membrane becomes more irregular in shape and non-smooth, and multiple platelet membrane ruptures are observed. Furthermore, the pseudopodia and protuberances become more numerous and slender, and the number of α-granules is significantly reduced. These morphological changes indicate that ageing may affect the function of platelets, which in turn affects the efficacy of platelet concentrates. Thus, the effects of age should be considered when using platelet concentrates prepared from elderly autologous blood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.