Evidence map›Paper›PMID 31486011›Full record

ArticleNeurochemical research2019

Functional Recovery Occurs Even After Partial Remyelination of Axon-Meshed Median and Ulnar Nerves in Mice.

Ana Elisa Speck, Jocemar Ilha, Daniel Fernandes Martins, Franciane Bobinski, Ana Paula Luiz, Adair Roberto Soares Dos Santos, Alessandra Swarowsky, Aderbal Silva Aguiar

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ana Elisa SpeckPrograma de Pós-Graduação em Fisioterapia, Centro do Ciências da Saúde e do Esporte, Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil. anaespeck@gmail.com.ORCID http://orcid.org/0000-0003-4084-522X
Jocemar IlhaPrograma de Pós-Graduação em Fisioterapia, Centro do Ciências da Saúde e do Esporte, Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil.
Daniel Fernandes MartinsLaboratório de Neurobiologia da Dor e Inflamação (LANDI), Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Franciane BobinskiLaboratório de Neurobiologia da Dor e Inflamação (LANDI), Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Ana Paula LuizLaboratório de Neurobiologia da Dor e Inflamação (LANDI), Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Adair Roberto Soares Dos SantosLaboratório de Neurobiologia da Dor e Inflamação (LANDI), Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Alessandra SwarowskyPrograma de Pós-Graduação em Fisioterapia, Centro do Ciências da Saúde e do Esporte, Universidade do Estado de Santa Catarina (UDESC), Florianópolis, SC, Brazil.
Aderbal Silva AguiarResearch Group on Biology of Exercise, Department of Health Sciences, UFSC-Federal University of Santa Catarina, Araranguá, SC, 88905-120, Brazil.
Universidade Federal de Santa Catarina · BRUniversidade do Estado de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Upper limb nerve injuries are common, and their treatment poses a challenge for physicians and surgeons. Experimental models help in minimum exploration of the functional characteristics of peripheral nerve injuries of forelimbs. This study was conducted to characterize the functional recovery (1, 3, 7, 10, 14, and 21 days) after median and ulnar nerve crush in mice and analyze the histological and biochemical markers of nerve regeneration (after 21 days). Sensory-functional impairments appeared after 1 day. The peripheral nerve morphology, the nerve structure, and the density of myelin proteins [myelin protein zero (P0) and peripheral myelin protein 22 (PMP22)] were analyzed after 21 days. Cold allodynia and fine motor coordination recovery occurred on the 10th day, and grip strength recovery was observed on the 14th day after injury. After 21 days, there was partial myelin sheath recovery. PMP22 recovery was complete, whereas P0 recovery was not. Results suggest that there is complete functional recovery even with partial remyelination of median and ulnar nerves in mice.

Indexed as

Recovery of FunctionRemyelinationAnimalsMaleMedian NerveMiceMyelin P0 ProteinMyelin ProteinsNerve CrushUlnar NerveMyelin P0 ProteinMyelin ProteinsPmp22 protein, ratAxonotmesisMedian nerveMyelinStrengthUlnar nerve

Identifiers

PMID31486011
OpenAlexW2971447247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.