Evidence map›Paper›PMID 31485928›Full record

SynthesisSurgical endoscopy2020

The incidence of iron deficiency anemia post-Roux-en-Y gastric bypass and sleeve gastrectomy: a systematic review.

Ghada Enani, Elif Bilgic, Ekaterina Lebedeva, Megan Delisle, Ashley Vergis, Krista Hardy

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ghada EnaniDepartment of General Surgery, University of Manitoba, 409 Taché Avenue, Winnipeg, MB, R2H 2A6, Canada. ghada.enani@gmail.com.ORCID http://orcid.org/0000-0003-4379-0543
Elif BilgicHenry K.M. DeKuyper Education Centre, McGill University, 1650 Cedar Avenue, Montreal, H3G 1A4, Canada.
Ekaterina LebedevaHenry K.M. DeKuyper Education Centre, McGill University, 1650 Cedar Avenue, Montreal, H3G 1A4, Canada.
Megan DelisleDepartment of General Surgery, University of Manitoba, 409 Taché Avenue, Winnipeg, MB, R2H 2A6, Canada.
Ashley VergisDepartment of General Surgery, University of Manitoba, 409 Taché Avenue, Winnipeg, MB, R2H 2A6, Canada.
Krista HardyDepartment of General Surgery, University of Manitoba, 409 Taché Avenue, Winnipeg, MB, R2H 2A6, Canada.
University of Manitoba · CAMcGill University · CAKing Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

settingThe physiological and anatomical changes that occur as a consequence of bariatric surgery result in macro- and micro-nutritional deficiencies, especially iron deficiency. The reported incidence of iron deficiency and associated anemia after bariatric surgery varies widely across studies.

objectivesThe aim of this systematic review is to quantify the impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on the incidence of iron deficiency.

methodsDatabases including Ovid Medline, Ovid Embase, Helthstar, Scopus, Cochrane (CDSR), LILACS, and ClinicalKey were searched for original articles with additional snowballing search. Search terms included Obesity, nutrient deficiency, iron deficiency, iron deficiency anemia, bariatric surgery, Roux-en-Y gastric bypass, and sleeve gastrectomy. Original articles reporting the incidence of iron deficiency and anemia pre- and post-RYGB and SG from January 2000 to January 2015 with minimum 1-year follow-up were selected. Data extraction from selected studies was based on protocol-defined criteria.

resultsThere were 1133 articles screened and 20 studies were included in the final analysis. The overall incidence of iron deficiency was 15.2% pre-operatively and 16.6% post-operatively. When analyzed by procedure, the incidence of iron deficiency was 12.9% pre-RYGB versus 24.5% post-RYGB and 36.6% pre-SG versus 12.4% post-SG. The incidence of iron deficiency-related anemia was 16.7% post-RYGB and 1.6% post-SG. Risk factors for iron deficiency were premenopausal females, duration of follow-up, and pre-operative iron deficiency. Prophylactic iron supplementation was reported in 16 studies and 2 studies provided therapeutic iron supplementation only for iron-deficient patients. Iron dosage varied from 7 to 80 mg daily across studies.

conclusionIron deficiency is frequent in people with obesity and may be exacerbated by bariatric surgery, especially RYGB. Further investigation is warranted to determine appropriate iron supplementation dosages following bariatric surgery. Careful nutritional surveillance is important, especially for premenopausal females and those with pre-existing iron deficiency.

Indexed as

AdultAnemia, Iron-DeficiencyBariatric SurgeryFemaleGastrectomyGastric BypassHumansIncidenceIronMaleMiddle AgedObesityObesity, MorbidPostoperative ComplicationsPremenopauseRisk FactorsIronBariatric surgeryIron deficiencyIron deficiency anemiaSystematic review

Identifiers

PMID31485928
OpenAlexW2971839834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.