Evidence map›Paper›PMID 31485910›Full record

SynthesisInternational urology and nephrology2019

Infectious complications and mortality associated with the use of IV iron therapy: a systematic review and meta-analysis.

Sohail Abdul Salim, Wisit Cheungpasitporn, Ahmad Elmaraezy, Omar Jawafi, Md Rahman, Narothama Reddy Aeddula, Raghavendra Tirupathi, Tibor Fülöp

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Sohail Abdul SalimDepartment of Internal Medicine, Division of Nephrology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216-4505, USA. sohail3553@gmail.com.
Wisit CheungpasitpornDepartment of Internal Medicine, Division of Nephrology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216-4505, USA.
Ahmad ElmaraezyAl-Razi Medical Research Academy, Cairo, Egypt.
Omar JawafiComputational and Data-Enabled Science, Jackson State University, Jackson, MS, USA.
Md RahmanComputational and Data-Enabled Science, Jackson State University, Jackson, MS, USA.
Narothama Reddy AeddulaDeaconess Health System, Evansville, IN, USA.
Raghavendra TirupathiKeystone Health, Chambersburg, PA, USA.
Tibor FülöpDivision of Nephrology, Department of Internal Medicine, Medical University of South Carolina, Charleston, SC, USA.
Jackson State University · USDeaconess Hospital · USMedical University of South Carolina · USState Street (United States) · USUniversity of Mississippi Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParental iron is used to optimize hemoglobin and enhance erythropoiesis in end-stage renal disease along with erythropoietin-stimulating agents. Safety of iron has been debated extensively and there is no definite evidence whether parenteral iron increases the risk of infections and mortality. We performed this meta-analysis to evaluate the incidence of infectious complications, hospitalizations and mortality with use of parenteral iron.

methodsMedical electronic databases [PubMed, EMBASE, Scopus, Web of Science, and cochrane central register for controlled clinical trials (CENTRAL)] were queried for studies that investigated the association between intravenous iron administration and infection in hemodialysis patients. 24 studies (8 Randomized control trials (RCTs) and 16 observational studies) were considered for qualitative and quantitative analysis.

resultsAll-cause mortality Data from 6 RCTs show that high-dose IV iron conferred 17% less all-cause mortality compared to controls; however, this outcome was not statistically significant (OR = 0.83, CI [0.7, 1.01], p = 0.07). Nine observational studies were pooled under the random effects model due to significant heterogeneity (I

conclusionHigh-dose parenteral iron does not seem to be associated with higher risk of infection, all-cause mortality, increased hospitalization or increased cardiovascular events on analysis of RCTs. Observational studies show increased risk for all-cause mortality, infections and hospitalizations that were not statistically significant and were associated with significant heterogeneity.

Indexed as

Administration, IntravenousAnemiaHospitalizationHumansIncidenceInfectionsIronKidney Failure, ChronicObservational Studies as TopicRandomized Controlled Trials as TopicIronAnemiaESRDInfectionsMeta-analysisMortality

Identifiers

PMID31485910
OpenAlexW2972301720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.