Evidence map›Paper›PMID 31485904›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2020

The Clinical Value of Fluorescent Lymphography with Indocyanine Green During Robotic Surgery for Gastric Cancer: a Matched Cohort Study.

Fabio Cianchi, Giampiero Indennitate, Beatrice Paoli, Manuela Ortolani, Gabriele Lami, Natalia Manetti, Ottaviano Tarantino, Sara Messeri, Caterina Foppa, Benedetta Badii and 6 more

2 registry-linked trialsOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 10 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04219332 phase3unknown statusnot on this map

Comparison of Submucosal and Subserosal Approaches Toward Optimized Indocyanine Green Tracer-Guided Laparoscopic Lymphadenectomy for Patients With Gastric Cancer: The FUGES-019 Randomized Clinical Trial

TypeinterventionalSponsorFujian Medical UniversityRan2019 to 2023Enrolled266ConditionsIndocyanine Green, Gastric Cancer, Injection SiteArmsSubserosa injection of indocyanine green, submucosal injection of indocyanine green
NCT04973475 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Prospective Clinical Trials on Clinical Outcomes of Indocyanine Green Tracer Using in Laparoscopic Distal Gastrectomy With Lymph Node Dissection for Early Gastric Cancer

TypeinterventionalSponsorFujian Medical UniversityRan2021 to 2026Enrolled180ConditionsEarly Gastric Cancer, Indocyanine Green, Lymph Node DissectionArmsIndocyanine Green
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 10 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Fabio CianchiCenter for Oncological Minimally Invasive Surgery (COMIS), Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy. fabio.cianchi@unifi.it.ORCID http://orcid.org/0000-0002-6936-8693
Giampiero IndennitateIFCA, Florence, Italy.
Beatrice PaoliIFCA, Florence, Italy.
Manuela OrtolaniIFCA, Florence, Italy.
Gabriele LamiGastroenterology Unit, Careggi University Hospital, Florence, Italy.
Natalia ManettiGastroenterology Unit, Careggi University Hospital, Florence, Italy.
Ottaviano TarantinoGastroenterology Unit, San Giuseppe Hospital, Empoli, Italy.
Sara MesseriGastroenterology Unit, San Giuseppe Hospital, Empoli, Italy.
Caterina FoppaHumanitas Clinical and Research Hospital, Milan, Italy.
Benedetta BadiiCenter for Oncological Minimally Invasive Surgery (COMIS), Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Luca NovelliPathology Unit, Careggi University Hospital, Florence, Italy.
Ileana SkalameraCenter for Oncological Minimally Invasive Surgery (COMIS), Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Tommaso NelliCenter for Oncological Minimally Invasive Surgery (COMIS), Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Francesco CorattiCenter for Oncological Minimally Invasive Surgery (COMIS), Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Giuliano PerigliCenter for Oncological Minimally Invasive Surgery (COMIS), Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Fabio StaderiniCenter for Oncological Minimally Invasive Surgery (COMIS), Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · ITOspedale San Giuseppe · ITHumanitas University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNear-infrared (NIR) fluorescence imaging with indocyanine green (ICG) has been recently introduced for lymphatic mapping in several tumors. We aimed at investigating whether this technology may improve the intraoperative visualization of lymph nodes during robotic gastrectomy for gastric cancer.

methodsBetween June 2014 and June 2018, a total of 94 patients underwent robotic gastrectomy with D2 lymph node dissection for gastric cancer. In 37 patients, ICG was injected endoscopically into the submucosal layer around the tumor the day before surgery. After propensity score matching, the results of these 37 patients were compared with the results of 37 control patients who had undergone robotic gastrectomy without ICG injection.

resultsAmong the 37 patients within the ICG group, no adverse events related to ICG injection or intraoperative NIR imaging occurred. After completion of D2 lymph node dissection, no residual fluorescent lymph nodes were left in the surgical field. A mean of 19.4 ± 14.7 fluorescent lymph nodes was identified per patient. The mean total number of harvested lymph nodes was significantly higher in the ICG group than in the control group (50.8 vs 40.1, P = 0.03). In the ICG group, 23 patients had metastatic lymph nodes. The accuracy, sensitivity, and specificity of ICG fluorescence for metastatic lymph nodes were 62.2%, 52.6%, and 63.0%, respectively.

conclusionOur study indicates that NIR imaging with ICG may provide additional node detection during robotic surgery for gastric cancer. Unfortunately, this technique failed to show good selectivity for metastatic lymph nodes.

Indexed as

Robotic Surgical ProceduresStomach NeoplasmsCohort StudiesFluorescent DyesHumansIndocyanine GreenLymph NodesLymphographyFluorescent DyesIndocyanine GreenGastric cancerIndocyanine greenLymph nodeNear-infrared fluorescenceRobotic gastrectomy

Identifiers

PMID31485904
OpenAlexW2971982746

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.