Evidence map›Paper›PMID 31485889›Full record

ReviewMolecular imaging and biology2020

The Current Role of Microfluidics in Radiofluorination Chemistry.

Karla-Anne Knapp, Michael L Nickels, H Charles Manning

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. High-efficiency [EJNMMI radiopharmacy and chemistry · 2025
    Article
  2. Production of [EJNMMI radiopharmacy and chemistry · 2024
    Article
  3. Manufacturing 6-[Organic letters · 2024
    Article
  4. Microfluidic-based production of [EJNMMI radiopharmacy and chemistry · 2023
    Article
  5. Review
  6. Article
  7. [Scientific reports · 2023
    Article
  8. Production of [Molecules (Basel, Switzerland) · 2022
    Article
  9. Translating a radiolabeled imaging agent to the clinic.Advanced drug delivery reviews · 2022
    Review
  10. Article
  11. Optimization of Radiochemical Reactions using Droplet Arrays.Journal of visualized experiments : JoVE · 2021
    Article
  12. Article
  13. Nanotechnology Strategies for the Analysis of Circulating Tumor DNA: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karla-Anne KnappDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Michael L NickelsCenter for Molecular Probes, Vanderbilt University Medical Center, Nashville, TN, USA.
H Charles ManningDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA. henry.c.manning@vumc.org.

Funding

Vanderbilt In Vivo Cellular and Molecular Imaging CenterP50CA128323 · NCI · VANDERBILT UNIVERSITY · PI GORE, JOHN C · 2008 to 2012
$6.8M
NCI NIH HHS P50 CA128323
6 · The paper itself

Abstract

The current utilization of positron emission tomography (PET) imaging is limited due to the high costs associated with production facility start-up and operations; subsequently, there has been a movement towards microfluidic synthesis of radiolabeled imaging pharmaceuticals (tracers). In this review, we summarize the current status of microfluidic radiosynthesis units for producing fluorine-18 labeled PET imaging tracers, including a discussion of the relative strengths and weaknesses of such devices. In addition, we provide a brief overview of the radiotracers that have been produced using microfluidic devices to date. Finally, we discuss the prospects for the future of this field, including the potential of newly envisioned devices developed that may allow operators to easily synthesize specialized tracers for individual patient doses.

Indexed as

AnimalsFluorine RadioisotopesHumansIsotope LabelingMicrofluidicsPositron-Emission TomographyRadiopharmaceuticalsFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsFluorine-18MicrofluidicPositron emission tomographyRadiosynthesis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.