ReviewJournal of ophthalmic inflammation and infection2019
The broad spectrum of application of optical coherence tomography angiography to the anterior segment of the eye in inflammatory conditions: a review of the literature.
Review in Journal of ophthalmic inflammation and infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- 23G Minimally Invasive Vitrectomy Combined with Glaucoma Drainage Valve Implantation and Phacoemulsification Cataract Extraction for Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy with Vitreous Hemorrhage.Computational and mathematical methods in medicine · 2022Trial
- Tumor or Inflammation? How Multi-Modality Image Fusion and Shear Wave Elastography Can Help Solve the Diagnostic Dilemma.Diagnostics (Basel, Switzerland) · 2026Review
- Vessel-Sparing Rectus Plication Surgery vs Recession/Resection: A Comparative Optical Coherence Tomography Angiography (OCT-A) Analysis of Iris Vessel Density Changes.Beyoglu eye journal · 2026Article
- Conjunctival vascularization assessed by AS-OCTA as a biomarker of ocular involvement in primary Sjögren's syndrome.Rheumatology advances in practice · 2026Article
- Quantifying anterior segment vascular changes in thyroid eye disease using optical coherence tomography angiography.BMC medical imaging · 2025Article
- Iris Microcirculation After Selective Laser Trabeculoplasty: A Pilot Optical Coherence Tomography Angiography Study.Vision (Basel, Switzerland) · 2025Article
- Current clinical applications of anterior segment optical coherence tomography angiography: a review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Review
- OCT Angiography in Noninfectious Uveitis: A Description of Five Cases and Clinical Applications.Diagnostics (Basel, Switzerland) · 2023Article
- Imaging of iris vasculature: current limitations and future perspective.Eye (London, England) · 2022Review
- Role of Anterior Segment-Optical Coherence Tomography Angiography in Acute Ocular Burns.Diagnostics (Basel, Switzerland) · 2022Review
- Longitudinal Assessment of Alkali Injury on Mouse Cornea Using Anterior Segment Optical Coherence Tomography.Translational vision science & technology · 2021Article
- Advances and Current Clinical Applications of Anterior Segment Optical Coherence Tomography Angiography.Frontiers in medicine · 2021Review
- Imaging Inflammation - From Whole Body Imaging to Cellular Resolution.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith an increased number of papers on how to interpret optical coherence tomography angiography (OCTA) findings in uveitis, the aim of this review is to assess its efficacy for the quantitative monitoring of structural and functional changes in inflamed conjunctiva and iris vessels in patients with acute anterior uveitis and iris neovascularization. MAIN BODY: OCTA, currently designed as a retinal vascular imaging system, has been recently adapted for anterior segment and showed good potential for successful imaging of the conjunctiva, the cornea, and the iris. OCTA can successfully delineate corneal vessels with substantial image quality. At the same time, it can detect changes in conjunctival and limbal vascularization and thus can be applied to pseudo-inflammatory conditions such as pterygium. Anterior segment OCTA allows analysis of iris vasculature and 3-D reconstruction of the normal iris vessels. OCTA can determined iris vessel filling defects or their flow increase, when present, secondary to inflammatory conditions. In addition, OCTA gives qualitative vessel density values that can be compared pre- and post-anti-inflammatory treatment. OCTA for imaging of the iris vasculature in health and disease is highly dependent on iris pigmentation. In both OCTA and fluorescein angiography, iris pigmentation causes vasculature imaging blockage, but OCTA provides more detailed iris vasculature images. Fine, clinically invisible iris vessels can be visualized by OCTA in the very early stages as well as in the regressed stage of NVI. Additional studies including different iris pathologies are needed to determine the most optimal scanning parameters in OCTA of the anterior segment.
conclusionsThis review aims to establish the current application of OCTA to anterior segment disorders of the eye, with an emphasis on exploring its use in iris vessel dilation seen in various forms of iritis, as a predictive factor for further episodes of inflammation. In addition, OCTA can depict neovascularization of the iris secondary to proliferative diabetic retinopathy.
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