ArticleJournal of assisted reproduction and genetics2019
The impact of peak estradiol during controlled ovarian stimulation on the cumulative live birth rate of IVF/ICSI in non-PCOS patients.
Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Are We Considering All the Potential Drug-Drug Interactions in Women's Reproductive Health? A Predictive Model Approach.Pharmaceutics · 2025Article
- Embryo utilisation rate and transferable embryo to oocyte ratio correlate positively with livebirth rate but negatively with oocyte number: analysis of 14,156 fresh IVF/ICSI cycles.Journal of ovarian research · 2025Article
- Impact of Elevated Oestrogen Levels on hCG Trigger Day on Clinical Pregnancy Outcome and OHSS Incidence in Long-Acting GnRHa Down-Regulated IVF/ICSI-ET Cycles.International journal of women's health · 2025Article
- Unlocking Success: The Optimal Gonadotrophin Starting Point for Luteal-Phase Stimulation in IVF Patients with Normal Responses.International journal of women's health · 2025Article
- Molecular Determinants of Uterine Receptivity: Comparison of Successful Implantation, Recurrent Miscarriage, and Recurrent Implantation Failure.International journal of molecular sciences · 2023Review
- Which transfer day results in the highest live birth rate for PCOS patients undergoing in vitro fertilization?BMC pregnancy and childbirth · 2023Article
- The pathophysiological role of estrogens in the initial stages of pregnancy: molecular mechanisms and clinical implications for pregnancy outcome from the periconceptional period to end of the first trimester.Human reproduction update · 2023Review
- The effect of peak serum estradiol level during ovarian stimulation on cumulative live birth and obstetric outcomes in freeze-all cycles.Frontiers in endocrinology · 2023Article
- Prediction of miscarriage in first trimester by serum estradiol, progesterone and β-human chorionic gonadotropin within 9 weeks of gestation.BMC pregnancy and childbirth · 2022Article
- High levels estradiol affect blastocyst implantation and post-implantation development directly in mice.Biomedical journal · 2022Article
- The Association Between Serum Estradiol Levels on hCG Trigger Day and Live Birth Rates in Non-PCOS Patients: A Retrospective Cohort Study.Frontiers in endocrinology · 2022Article
- Effect of Hyperinsulinemia and Insulin Resistance on Endocrine, Metabolic, and Reproductive Outcomes in Non-PCOS Women Undergoing Assisted Reproduction: A Retrospective Cohort Study.Frontiers in medicine · 2021Article
- Clinical significance of combined detection of anti-Mullerian hormone and follicular output rate in women of late reproductive age.American journal of translational research · 2021Article
- Cumulative Live Birth Rates After the First ART Cycle Using Flexible GnRH Antagonist Protocol vs. Standard Long GnRH Agonist Protocol: A Retrospective Cohort Study in Women of Different Ages and Various Ovarian Reserve.Frontiers in endocrinology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe study aimed to investigate the impact of the peak E2 level during controlled ovarian hyperstimulation (COS) on the cumulative live birth rate (cLBR) in non-PCOS women with normal ovarian reserve. MATERIALS AND
methodsWomen between 20 and 39 years were included. Donor cycles and patients who never experienced embryo transfer were excluded. Multivariable regression and smooth curve fitting were applied for statistical analysis.
resultsA total of 1141 patients were included. The mean age, basal AFC, peak E2 level, and number of retrieved oocyte were 30.0 ± 3.7 years old, 16.8 ± 6.7, 3911.0 ± 1302.9 pg/ml, and 13.6 ± 5.5, respectively. In the overall population of the cohort, cLBR, miscarriage rate, and preterm birth rate were 66.9%, 7.4%, and 13.7%, respectively. The results of multivariable regression analysis failed to show the impact of peak E2 on the cLBR [OR (95%CI) 0.995 (0.982, 1.009), P = 0.486]. However, the result of smooth curve fitting indicated that when the peak E2 was lower than 2185 pg/ml, the cLBR increased about 12% with 100 pg/ml increasing of the peak E2. When the peak E2 was higher than 6136 pg/ml, the cLBR decreased about 10% with 100 pg/ml increasing of the peak E2.
conclusionWe concluded that the peak E2 level on hCG trigger day is associated with the cLBR in a segmental pattern. There should be an appropriate range of the peak E2 level during COS to achieve a relative best cLBR in non-PCOS patients using stimulating protocol mainly based on GnRH agonist; however, the cutoff value must vary in different centers.
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