ArticleOncology reports2019
miR‑139‑3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A.
Article in Oncology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 26 citations in OpenAlex.
- MiR-139 modulates CD8iScience · 2026Article
- A circulating microRNA-based diagnostic model for breast cancer, in which the miR-139-3p/RPA2 axis regulates the sensitivity to DNA-damaging agents.Translational cancer research · 2026Article
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- C118P Suppresses Gastric Cancer Growth via Promoting Autophagy-Lysosomal Degradation of RAB1A.Pharmaceutics · 2024Article
- Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model.Scientific reports · 2023Article
- MicroRNAs: A Link between Mammary Gland Development and Breast Cancer.International journal of molecular sciences · 2022Review
- MiR-139-3p Targets CHEK1 Modulating DNA Repair and Cell Viability in Lung Squamous Carcinoma Cells.Molecular biotechnology · 2022Article
- miR-139-3p/Kinesin family member 18B axis suppresses malignant progression of gastric cancer.Bioengineered · 2022Article
- MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation.Journal of personalized medicine · 2022Article
- Maternal Exercise Programs Glucose and Lipid Metabolism and Modulates Hepatic miRNAs in Adult Male Offspring.Frontiers in nutrition · 2022Article
- MIMRDA: A Method Incorporating the miRNA and mRNA Expression Profiles for Predicting miRNA-Disease Associations to Identify Key miRNAs (microRNAs).Frontiers in genetics · 2022Article
- A critical appraisal of the circulating levels of differentially expressed microRNA in endometriosis†.Biology of reproduction · 2021Review
- Impact of Oncogenic Targets by Tumor-SuppressiveInternational journal of molecular sciences · 2021Article
- Highly connected, non-redundant microRNA functional control in breast cancer molecular subtypes.Interface focus · 2021Article
- MicroRNAs Possibly Involved in the Development of Bone Metastasis in Clear-Cell Renal Cell Carcinoma.Cancers · 2021Article
- Proteomic Characterization of Cytoplasmic Lipid Droplets in Human Metastatic Breast Cancer Cells.Frontiers in oncology · 2021Article
- Baicalein Induces Apoptosis of Pancreatic Cancer Cells by Regulating the Expression of miR-139-3p and miR-196b-5p.Frontiers in oncology · 2021Article
- Integrated Analysis of the m6A-Related lncRNA Identified lncRNA ABALON/miR-139-3p/Cancer management and research · 2021Article
- MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer.Molecular medicine reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulated evidence indicates that aberrant microRNAs (miRNAs) expression plays an important role in the initiation and progression of various cancers, including breast cancer. Previous studies suggested that miR‑139‑3p might serve as a tumor suppressor and is downregulated in several cancer types. However, the expression patterns and exact role of miR‑139‑3p in breast cancer remain to be elucidated. In this study, we aimed to analyze the effect of miR‑139‑3p on the progression of breast cancer and the mechanism involved. Through bioinformatics analysis and in vitro experimental studies, we found that miR‑139‑3p was decreased in breast cancer tissues and cell lines, and decreased miR‑139‑3p is associated with a poor prognosis in breast cancer patients. Overexpression of miR‑139‑3p by transfection significantly inhibits cell proliferation, migration, and invasion of breast cancer cells. Bioinformatics analysis and luciferase reporter gene assay confirmed that RAB1A was a potential target of miR‑139‑3p. Furthermore, overexpression of RAB1A counteracted the suppressing effects of miR‑139‑3p on breast cancer cell migration, invasion and epithelial‑to‑mesenchymal transition (EMT). Taken together, these data suggest that miR‑139‑3p plays a tumor suppressive role in breast cancer by targeting RAB1A and may serve as a potential new biomarker for breast cancer prognosis.
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Registered trials
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