Evidence map›Paper›PMID 31485557›Full record

ArticleJCO precision oncology2019

Response to Selective RET Inhibition With LOXO-292 in a Patient With

Robin Guo, Mark Schreyer, Jason C Chang, S Michael Rothenberg, Dahlia Henry, Paolo Cotzia, Mark G Kris, Natasha Rekhtman, Robert J Young, David M Hyman and 1 more

Abstract read
In one paragraph

Article in JCO precision oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Selpercatinib in Patients WithJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Trial
  4. Intracranial Efficacy of Selpercatinib inClinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Trial
  5. JCEM case reports · 2026
    Article
  6. Development and Characterization of a Patient-DerivedJTO clinical and research reports · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Salvage Therapy With Selpercatinib forJTO clinical and research reports · 2023
    Article
  12. Article
  13. Article
  14. Central Nervous System Disease in Patients With RET Fusion-Positive NSCLC Treated With Selpercatinib.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2023
    Article
  15. Article
  16. Review
  17. Response to Pralsetinib Observed in Meningeal-MetastaticJTO clinical and research reports · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Robin GuoMemorial Sloan Kettering Cancer Center, New York, NY.
Mark SchreyerMemorial Sloan Kettering Cancer Center, New York, NY.
Jason C ChangMemorial Sloan Kettering Cancer Center, New York, NY.
S Michael RothenbergLoxo Oncology, Stamford, CT.
Dahlia HenryLoxo Oncology, Stamford, CT.
Paolo CotziaNew York University Langone Medical Center, New York, NY.
Mark G KrisMemorial Sloan Kettering Cancer Center, New York, NY.
Natasha RekhtmanMemorial Sloan Kettering Cancer Center, New York, NY.
Robert J YoungMemorial Sloan Kettering Cancer Center, New York, NY.
David M HymanMemorial Sloan Kettering Cancer Center, New York, NY.
Alexander DrilonMemorial Sloan Kettering Cancer Center, New York, NY.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Investigational Cancer Therapeutics Training Program (ICTTP)T32CA009207 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Omar Abdel-Wahab, Alexander Drilon · 1985 to 2026
$13.7M
Institutional Career Development CoreKL2TR002385 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI YUAN-SHAN ZHU · 2017 to 2026
$13.3M
Summer research experiences for medical students supervised by faculty mentorsR25CA020449 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Charlotte Eielson Ariyan · 1985 to 2026
$6.2M
NCATS NIH HHS KL2 TR002385NCI NIH HHS P30 CA008748NCI NIH HHS R25 CA020449NCI NIH HHS T32 CA009207
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID31485557
PMCPMC6724540

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.