Evidence map›Paper›PMID 31485554›Full record

ArticleJBMR plus2019

Clinical Evaluation of Melorheostosis in the Context of a Natural History Clinical Study.

Smita Jha, Edward W Cowen, Tanya J Lehky, Katharine Alter, Lauren Flynn, James C Reynolds, Eileen Lange, James D Katz, Joan C Marini, Richard M Siegel and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. VEGF Secretion Drives Bone Formation in Classical MAP2K1+ Melorheostosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  7. Article
  8. International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Smita JhaClinical and Investigative Orthopedics Surgery Unit National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH Bethesda MD USA.ORCID 0000-0001-9201-3340
Edward W CowenDermatology Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH Bethesda MD USA.
Tanya J LehkyEMG Section, National Institutes of Neurological Disorders and Stroke (NINDS), NIH Bethesda MD USA.
Katharine AlterFunctional and Applied Biomechanics Section Rehabilitation Medicine Department, NIH Bethesda MD USA.
Lauren FlynnNational Institutes of Neurological Disorders and Stroke (NINDS), NIH Bethesda MD USA.
James C ReynoldsNuclear Medicine Division Radiology and Imaging Sciences, NIH Clinical Center Bethesda MD USA.
Eileen LangeOffice of the Clinical Director National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH Bethesda MD USA.
James D KatzOffice of the Clinical Director National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH Bethesda MD USA.
Joan C MariniSection on Heritable Disorders of Bone and Extracellular Matrix National Institute of Child Health and Human Development, NIH Bethesda MD USA.
Richard M SiegelImmunoregulation Section, Autoimmunity Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH Bethesda MD USA.
Timothy BhattacharyyaClinical and Investigative Orthopedics Surgery Unit National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH Bethesda MD USA.
National Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institute of Neurological Disorders and Stroke · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health · USNational Institutes of Health Clinical Center · US

Funding

TNF-receptors and programmed cell death in regulation of autoimmunityZIAAR041133 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI SIEGEL, RICHARD M · 2009 to 2019
$9.3M
6 · The paper itself

Abstract

Melorheostosis is a rare dysostosis involving cortical bone overgrowth that affects the appendicular skeleton. Patients present with pain, deformities, contractures, range of motion limitation(s), and limb swelling. It has been described in children as well as adults. We recently identified somatic mosaicism for gain-of-function mutations in

Indexed as

CANDLE‐WAX DISEASELERI'S DISEASEMAP2K1SCLEROTICSOMATIC MOSAIC

Identifiers

PMID31485554
PMCPMC6715778
OpenAlexW2953717334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.