Evidence map›Paper›PMID 31485553›Full record

ArticleJBMR plus2019

Downregulation of FGF Signaling by

Pauline Marangoni, Cyril Charles, Youngwook Ahn, Kerstin Seidel, Andrew Jheon, Bernhard Ganss, Robb Krumlauf, Laurent Viriot, Ophir D Klein

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Ectopic Activation ofInternational journal of molecular sciences · 2024
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Pauline MarangoniProgram in Craniofacial Biology and Department of Orofacial Sciences University of California San Francisco CA USA.ORCID 0000-0002-4355-7322
Cyril CharlesInstitut de Génomique Fonctionnelle de Lyon Univ Lyon, CNRS UMR 5242, ENS de Lyon, Université Claude Bernard Lyon 1 Lyon France.
Youngwook AhnStowers Institute for Medical Research Kansas City MO USA.
Kerstin SeidelProgram in Craniofacial Biology and Department of Orofacial Sciences University of California San Francisco CA USA.
Andrew JheonProgram in Craniofacial Biology and Department of Orofacial Sciences University of California San Francisco CA USA.ORCID 0000-0002-2014-2757
Bernhard GanssFaculty of Dentistry, University of Toronto ON Canada.
Robb KrumlaufStowers Institute for Medical Research Kansas City MO USA.ORCID 0000-0001-9102-7927
Laurent ViriotInstitut de Génomique Fonctionnelle de Lyon Univ Lyon, CNRS UMR 5242, ENS de Lyon, Université Claude Bernard Lyon 1 Lyon France.
Ophir D KleinProgram in Craniofacial Biology and Department of Orofacial Sciences University of California San Francisco CA USA.ORCID 0000-0002-6254-7082
University of California, San Francisco · USStowers Institute for Medical Research · USUniversité Claude Bernard Lyon 1 · FRUniversity of Toronto · CA

Funding

Harnessing natural stem cell-based strategies for mammalian dental renewalR35DE026602 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2016 to 2023
$8.0M
Regulation of organogenesis through regional variations in tissue mechanicsR01DE027620 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CAMPAS, OTGER, KLEIN, OPHIR D · 2018 to 2022
$2.3M
NIDCR NIH HHS R01 DE027620NIDCR NIH HHS R35 DE026602
6 · The paper itself

Abstract

FGF signaling plays a critical role in tooth development, and mutations in modulators of this pathway produce a number of striking phenotypes. However, many aspects of the role of the FGF pathway in regulating the morphological features and the mineral quality of the dentition remain unknown. Here, we used transgenic mice overexpressing the FGF negative feedback regulator Sprouty4 under the epithelial keratin 14 promoter (K14-

Indexed as

ENAMEL MINERALIZATION DEFECTFGF SIGNALINGSPRY4TOOTH DEVELOPMENT

Identifiers

PMID31485553
PMCPMC6715786
OpenAlexW2944870159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.