Evidence map›Paper›PMID 31485551›Full record

ArticleJBMR plus2019

Longitudinal Evaluation of Pain, Flare-Up, and Emotional Health in Fibrodysplasia Ossificans Progressiva: Analyses of the International FOP Registry.

Ke Peng, Kin Cheung, Arielle Lee, Christine Sieberg, David Borsook, Jaymin Upadhyay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  15. Pain Phenotypes in Rare Musculoskeletal and Neuromuscular Diseases.Neuroscience and biobehavioral reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ke PengCenter for Pain and the Brain Department of Anesthesiology Critical Care and Pain Medicine Boston Children's Hospital Harvard Medical School Boston MA USA.
Kin CheungBioSAS Consulting, Inc. Wellesley MA USA.
Arielle LeeCenter for Pain and the Brain Department of Anesthesiology Critical Care and Pain Medicine Boston Children's Hospital Harvard Medical School Boston MA USA.
Christine SiebergCenter for Pain and the Brain Department of Anesthesiology Critical Care and Pain Medicine Boston Children's Hospital Harvard Medical School Boston MA USA.
David BorsookCenter for Pain and the Brain Department of Anesthesiology Critical Care and Pain Medicine Boston Children's Hospital Harvard Medical School Boston MA USA.
Jaymin UpadhyayCenter for Pain and the Brain Department of Anesthesiology Critical Care and Pain Medicine Boston Children's Hospital Harvard Medical School Boston MA USA.
Harvard University · USBoston Children's Hospital · USCenter for Pain and the Brain · USWellesley College · US

Funding

Pediatric Persistent Post-surgical Pain: From Animals to Application (Supplement)K23GM123372 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI SIEBERG, CHRISTINE BARRETT · 2016 to 2020
$573k
NIGMS NIH HHS K23 GM123372
6 · The paper itself

Abstract

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, inherited, connective tissue disease with ∼800 documented cases worldwide. The principal pathological feature of FOP is the transition of skeletal muscle, tendons, ligaments, and fascia into cartilage and bone. This heterotopic ossification (HO) is often preceded by painful soft tissue swellings or flare-ups that may last several months. For many individuals, experiencing a flare-up may represent a worsening of their condition and contribute to feelings of anxiety or suppressed affect, both of which are well-recognized to exacerbate pain perception. To date, much remains unknown regarding the dynamics of pain and emotional health in FOP during flare-up and also quiescent, non-flare-up disease phases. In order to elucidate the occurrence and effect of pain in FOP, this study analyzed Patient-Reported Outcomes Measurement Information System-based questionnaires completed by 99 patients participating in the international FOP Registry over a 30-month period. We observed that although moderate to severe pain (≥4, 0 to 10 pain scale) was commonly associated with flare-ups (56% to 67%), surprisingly, 30% to 55% of patients experienced similar pain levels during non-flare-up states. In those patients reporting pain levels of ≥4, 45% to 74% of patients report experiencing anxiety, depression, or irritability, with 36% to 48% reporting emotional problems during no to mild pain states. Furthermore, independent of the flare-up status, the severity of pain in FOP patients was found to be significantly anti-correlated with emotional health, physical health, and overall quality-of-life. These findings strongly suggest the need for an improved understanding of pain and emotional health in FOP during flare-up and quiescent periods. © 2019 The Authors.

Indexed as

EMOTIONAL HEALTHFIBRODYSPLASIA OSSIFICANS PROGRESSIVAFLARE‐UPPAINPHYSICAL HEALTH

Identifiers

PMID31485551
PMCPMC6715827
OpenAlexW2913698357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.