Evidence map›Paper›PMID 31485321›Full record

ArticleMalaria research and treatment2019

Prevalence and Factors Associated with Acute Kidney Injury among Malaria Patients in Dar es Salaam: A Cross-Sectional Study.

M S Muhamedhussein, S Ghosh, K Khanbhai, E Maganga, Z Nagri, M Manji

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Article in Malaria research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

M S MuhamedhusseinRegency Medical Center, P.O. Box 2029, Dar es Salaam, Tanzania.ORCID https://orcid.org/0000-0002-0901-4906
S GhoshRegency Medical Center, P.O. Box 2029, Dar es Salaam, Tanzania.
K KhanbhaiRegency Medical Center, P.O. Box 2029, Dar es Salaam, Tanzania.ORCID https://orcid.org/0000-0003-2981-4318
E MagangaRegency Medical Center, P.O. Box 2029, Dar es Salaam, Tanzania.
Z NagriApollo Medical Centre, Dar es Salaam, Tanzania.
M ManjiEbrahim Haji Charitable Health Centre, Dar es Salaam, Tanzania.ORCID https://orcid.org/0000-0001-8837-0230

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFalciparum malaria still remains as a major cause of morbidity and mortality worldwide. Acute kidney injury is a known complication of malaria, and it is reported to occur in up to 40% of adult patients with severe falciparum malaria in endemic regions like sub-Saharan Africa.

objectivesTo determine the prevalence and factors associated with acute kidney injury among falciparum malaria patients in a tertiary level private hospital in Dar es Salaam. METHODOLOGY: In a cross-sectional study design, 104 adults with falciparum malaria were enrolled consecutively over 6 months from April to September 2015. The diagnosis of acute kidney injury (AKI) in these patients was established using the KDIGO classification criteria. The prevalence of AKI was obtained at 48 hours from admission and at day 7. Different sociodemographic and clinical parameters which were associated with acute kidney injury at 48 hours and at day 7 were identified by hypothesis testing using chi squared tests followed by multivariate logistic regression analysis. Factors with a p value less than 0.05 were considered significant.

resultsThe participants were predominantly males 65.4% (68/104) and a third (36.5% (38/104)) were between 46 and 65 years. The prevalence of AKI among malaria patients at 48 hours was 26% (27/104). The prevalence of AKI among malaria patients at day 7 was 18.3% (19/104). On multivariate logistic regression, we found that factors that were significantly associated with AKI at 48 hours were male sex (OR 127, CI 3.4-4700, P = 0.008) and hemoglobin <7.5g/dl (OR 36.5, CI 1.7-797.7, P = 0.022), and factor associated with AKI at day 7 was baseline platelet count <25×10

conclusionAcute kidney injury is a common complication in patient with falciparum malaria. When managed well it has an excellent prognosis and necessitates dialysis in only a minority of patients. Male sex and hemoglobin is associated with AKI at 48 hours and baseline platelet count is associated with AKI at 7 days.

Identifiers

PMID31485321
PMCPMC6702846
OpenAlexW2964993128

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.